2-Methylbutanoic Acid CAS 116-53-0

Chinese invention application patents CN200310106387.0 and CN97104420.1 disclose the preparation method of 2-methylbutyric acid, which mainly uses food or other natural plants as raw materials, and the by-product fusel alcohol produced after fermentation is subjected to rectification and separation to obtain 2-methylbutyric acid. Methyl butanol is oxidized to 2-methyl butyric acid with 2-methyl butanol as the raw material, and the GC content of 2-methyl butyric acid is about 98% after rectification.

Shi Quan et al. used natural 2-methylbutanol as the starting material to obtain active 2-methylbutyric acid through hydrogen peroxide oxidation, and the optical rotation at 20°C was +18.0°. 

Huang Yongxue et al. used 2-ethylacrolein as a raw material to synthesize 2-methylbutyric acid through continuous reduction and oxidation two-step reaction. The process provided was scaled up to produce 2-methylbutyric acid. , GC≥99.5%. The steps and process conditions are as follows:

The first step: put 2-ethylacrolein and acetone solvent into the reactor, stir well, put 5% palladium carbon or 10% palladium carbon, after nitrogen replacement, feed hydrogen to 1 atmosphere, and control the temperature at 20-60 After the reaction, the solid catalyst was removed by filtration to obtain an intermediate solution.

Step 2: Add 1-5mol% sodium tungstate to the above intermediate solution, and slowly add 25-28% hydrogen peroxide solution dropwise at a temperature of 10-50°C. After the addition, keep warm until the raw material disappears as detected by TLC. The catalyst is filtered and recovered for reuse, the filtrate is distilled to obtain the crude product, and the pure product is obtained after rectification, the content is ≥99.5%, and the two-step yield is 88-93%.