2-Methyl-1-Phenyl-2-Propanol CAS 100-86-7

Benzyl chloride and metallic magnesium undertake Grignard response to generate benzyl magnesium chloride. Benzyl magnesium chloride is added to acetone and afterwards hydrolyzed to get dimethyl benzyl protoalcohol. This technique is preferable for commercial production.

In a 500mL three-necked flask outfitted with a stirrer, thermostat, reflux condenser (with drying out tube), going down channel and nitrogen filling tools, the tools are preheated and dried initially, filled with nitrogen to eliminate the air in the flask, and afterwards include 10.0 steel subsequently. Magnesium, 40.0 g tetrahydrofuran (or ether), a few grains of elemental iodine, a couple of declines of benzyl chloride, warm the hot water to trigger the reaction. After the response is completely started, begin stirring, and dropwise add 30.0 g benzyl chloride and 30.0 g tetrahydrofuran (or ether) of premix. Control the response temperature level to about 40 ° C by changing the going down speed. After the dropping is finished, mix for 15 minutes, and afterwards add dropwise a premix of 20.0 g benzyl chloride, 30.0 g acetone, and 30.0 g tetrahydrofuran (or 30.0 g ether + 50.0 g toluene). Also regulate the going down rate to make sure that the reaction temperature is less than 45 ° C. After the trickling is finished, stir the response at space temperature for 1 hour. Get rid of the nitrogen filling gadget. At space temperature, put the response service into 200g of 20% ammonium chloride option for hydrolysis. Stir for 1 hour. Add 200g of 5% hydrochloric acid solution. Leave to separate and separate. Take the oil layer. Laundry with saturated Na2CO3 aqueous solution and twice with brine until neutral to acquire crude 2-Methyl-1-Phenyl-2-Propanol. The return can get to greater than 80%. Include the crude product into a 250mL three-necked flask and accomplish fractionation under lowered stress to get about 45g of item with a web content of greater than 98% (GC technique).

The pureness of the product manufactured by this method has been greatly enhanced, and the fragrance is a lot more spherical and plump. The synthesis technique has actually been substantially enhanced, and it is a perfect synthesis course.