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2-Hydroxy-5-Methylpyridine CAS 1003-68-5

Molecular Formula: C6H7NO

Formula Weight: 109.13

ZSpharmac: 2-Hydroxy-5-Methylpyridine Supplement

Product Name: 2-Hydroxy-5-Methylpyridine
CAS No: 1003-68-5
Purity: 99%

Basic Info

Product Name:2-Hydroxy-5-Methylpyridine
Other Names:2-Hydroxy-5-Methylpyridine, 98%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Chemical Raw Materials
Appearance:White or Pale Yellow Crystalline Powder
EINECS No.:213-713-9
Storage:Sealed in Dry,Room Temperature
Provide:2-Hydroxy-5-Methylpyridine MSDS;
2-Hydroxy-5-Methylpyridine COA

What is 2-Hydroxy-5-Methylpyridine?

2-Hydroxy-5-picoline is a pharmaceutical intermediate that can be used to prepare pirfenidone. Pirfenidone is a new pyridone compound with broad-spectrum anti-fibrotic effect, which is a white or light yellow crystalline powder.It can stop as well as reverse the formation of fibrosis and also scarring; as well as the medication additionally has an excellent impact on fibrotic conditions such as renal interstitial fibrosis and liver fibrosis; at the same time, it is additionally efficient in renal illness (focal segmental glomerulosclerosis). Signs and symptoms), hypertrophic cardiomyopathy, grown-up kind I neurofibromas, adolescent kind I neurofibromas as well as plexiform neurofibromas, diabetic issues with kidney condition, phase II scientific research studies of uterine leiomyomas, etc. Has a wide variety of applications.

2-Hydroxy-5-Methylpyridine Properties:

Melting point 183-187 °C (lit.)
Boiling point 304.2±15.0 °C(Predicted)
density 1.053±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
BRN 107074


2-Hydroxy-5-Methylpyridine Uses

  1. 2-Hydroxy-5-methylpyridine can stop and turn around the formation of fibrosis and also scarring; and the medication likewise has excellent curative impact on fibrotic illness such as renal interstitial fibrosis as well as liver fibrosis.
  2. 2-Hydroxy-5-picoline is also used in kidney disease (focal segmental glomerulosclerosis), hypertrophic cardiomyopathy, neurofibromatosis type I in adults, and neurofibromatosis type I in adolescents And plexiform neurofibromas, diabetes with kidney disease, uterine leiomyoma phase Ⅱ clinical research has been widely used.

Preparation of 2-Hydroxy-5-Methylpyridine

report one,
(1) Mix 2-amino-5-methylpyridine, diazotization reagent, and water evenly, cool to -4°C-3°C, add an acid solution for insulation reaction; after the reaction is complete, heat for hydrolysis and cooling, and then use mass A 30% sodium hydroxide solution is used to adjust the pH to 6.5-7.5, the organic phase is extracted with the first solvent, dried and concentrated under reduced pressure to obtain a crude 2-hydroxy-5-methylpyridine;

(2) Adding the second solvent to the crude 2-hydroxy-5-methylpyridine, heating to reflux, cooling and crystallization, suction filtration and drying to obtain pure 2-hydroxy-5-methylpyridine.

report two,
Mix 21.6g of 2-amino-5-picoline, 20.7g of diazotization reagent sodium nitrite and 40g of cold water at 5°C in a mixer to form a paste, then add ice to cool the paste to 0°C, Then, the paste was slowly poured into a continuously stirred hydrochloric acid solution with a concentration of 12% by mass, and the reaction was stirred at 0° C. for 1 hour to complete the reaction. Then heated to 95°C for 30min, cooled to 20°C, adjusted to pH 7 with 50% sodium hydroxide solution, heated to 60°C, extracted with ethyl acetate 150ml×5, and combined the organic layers , dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain 18.4 g of a pale yellow solid crude product; then 55 ml of anhydrous ethanol was added, heated to reflux for 1 h, cooled to 2°C, crystallized for 6 h, filtered with suction, and washed with anhydrous ethanol. , and dried at 50° C. for 8 hours to obtain 15.3 g of yellowish crystalline 2-hydroxy-5-picoline, with a yield of 70.2%.

report three.
Preparation of raw materials: Weigh 1000g of 5-methyl-3,4-dihydropyridine-2(1H)-one with a content of 95%, put it into a four-necked flask containing 1000g of chlorobenzene, stir to completely dissolve it and wait for it to be completely dissolved. use.

Pyridine phenol synthesis: The reaction process adopts a continuous flow micro-channel reactor, and feeds simultaneously according to the ratio of raw material pyridone chlorobenzene liquid to chlorine gas substance of 1:1.05. The temperature of the first three plates is 50 °C, and the temperature of the last three plates is 160 °C. In the fourth plate, a sodium carbonate aqueous solution (sodium carbonate content of 10%) of the same quality as pyridone was pumped. The residence time of the reaction material is controlled to be 90s by adjusting the flow rate of the pump, the pyridinephenol chlorobenzene liquid is continuously discharged and collected, and DMF (accounting for 12% by weight of pyridine) is added to it for the next reaction.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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