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Zhishang Chemical

2-Ethylhexyl Salicylate CAS 118-60-5

Molecular Formula: C15H22O3

Formula Weight: 250.33

ZSpharmac: 2-Ethylhexyl Salicylate Supplier

Product Name: 2-Ethylhexyl Salicylate
CAS No: 118-60-5
Purity: 99%

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Basic Info

Product Name:2-Ethylhexyl Salicylate
Other Names:Salicylic Acid 2-Ethylhexyl Ester
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:A Colourless Liquid
EINECS No.:204-263-4
Provide:2-Ethylhexyl Salicylate MSDS;
2-Ethylhexyl Salicylate COA

What is 2-Ethylhexyl Salicylate?

Isooctyl salicylate (also known as 2-Ethylhexyl Salicylate) is an important chemical product. Its appearance is a colorless to light yellow transparent liquid with a slightly aromatic smell. It absorbs UVB (Chinese: outdoor ultraviolet rays) It is widely used in perfume, soap, sunscreen cosmetics, and pharmaceutical industries, and can also be used as an organic solvent and an intermediate in organic synthesis. At present, my country mainly relies on imports.

2-Ethylhexyl Salicylate Property

Boiling point 189-190 °C/21 mmHg (lit.)
density 1.014 g/mL at 25 °C (lit.)
vapor pressure 0.018Pa at 20℃
refractive index n20/D 1.502(lit.)
Fp >230 °F
storage temp. Refrigerator
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form neat
color A colourless liquid.
Water Solubility 74.4μg/L at 20℃


Application of 2-Ethylhexyl Salicylate

CN201310583793.X discloses a moisturizing sunscreen, made of the following raw materials in parts by weight: 2-6 parts of dihydroxyacetone, 3-6 parts of polyoxyethylene sorbitan monostearate, 4 parts of ultrafine titanium dioxide -12 parts, stearic acid 2-5 parts, aloe powder 10-20 parts, endothelin antagonist 3-6 parts, cinnamic acid 4-8 parts, 2-Ethylhexyl Salicylate 10-20 parts, hydroxyethyl cellulose 15- 25 parts, isononyl isononanoate 8-16 parts, cyclomethicone 7-14 parts, cetyl dimethicone 6-12 parts, glyceryl monostearate 3 -9 parts, 2-4 parts of triethanolamine, 20-50 parts of deionized water. The invention provides a water-replenishing sunscreen which has anti-ultraviolet and sunscreen functions, and also has the functions of moisturizing, moisturizing, repairing skin wounds and replenishing moisture to the skin.

CN201610507292.7 discloses a moisturizing anti-wrinkle sunscreen, which is made of the following raw materials in parts by mass: 5-7 parts of glycerin, 3-5 parts of ethyl ethyl methoxycinnamate, 6-8 parts of isopropyl palmitate 4-5 parts of titanium dioxide, 3-5 parts of spermaceti, 8-11 parts of xanthan gum, 5-8 parts of superfine titanium dioxide, 3-4 parts of stearic acid, 12-16 parts of aloe vera powder, 5- 7 parts, 6-9 parts of 2-Ethylhexyl Salicylate, 8-11 parts of hydroxyethyl cellulose, 3-8 parts of cyclomethicone, 5-7 parts of green tea extract, 15-20 parts of water. The invention has moisturizing function and anti-wrinkle effect, good sun protection effect, long-lasting, mild and non-irritating, and can moisturize and maintain the skin.

CN201610769899.2 discloses a plant herbal sunscreen. The raw materials and weight ratios in the formula are: 8 parts of licorice extract, 2 parts of peppermint oil, 5 parts of seabuckthorn oil, 2 parts of fruit acid, 7 parts of rhubarb extract, 7 parts of jojoba oil, 20 parts of titanium dioxide, 10 parts of 2-Ethylhexyl Salicylate, 11 parts of hydroxyethyl cellulose, appropriate amount of essence, appropriate amount of preservative, 7 parts of glycerin, white oil to 100 parts. The dosage and physical and chemical properties of each raw material described in the present invention produce a synergistic effect, thereby achieving the effects of mild skin care, whitening and sun protection. The pH value of the invention is close to that of human skin, and is non-irritating to the skin; the skin is obviously comfortable, soft, and non-greasy after use, and has obvious effects of sun protection, skin care, whitening, and skin repair after sun exposure.

CN201110391715.0 discloses a sunscreen composition, which is made of the following raw materials in weight ratio, 2-Ethylhexyl Salicylate 1~5; paraffin oil 4~8; beeswax 8~15; microcrystalline wax 4~8; Vaseline 8~15; Dimethicone 0.5~1; Polyoxyethylene sorbitan monooleate 1~2; Deionized water 15~25; Tween 801~2. When making, add Tween 80 to deionized water and heat to 70°C as the water phase, then mix the remaining raw materials and heat to 70°C as the oil phase, mix the two phases for emulsification, after emulsification is uniform, cool to 30°C That’s it. The invention is simple to make, can effectively block ultraviolet rays, and can well protect the skin.

CN201410847008.1 discloses an air cushion BB cream with light-sensitive color uniformity and light and thin concealer effect, which is characterized in that: the weight percentage of its components is: 5-10% of natural ozokerite, 24-44% of moisturizing agent, 6% of lubricant -12%, oil 8-14%, emulsifier 6-10%, dispersant 11-21%, preservative 0.2%, hydrophobic pigment 1-4%, thickener 2-9%, superfine pearl powder 4-8%, squalane 4-8%, cyclopentasiloxane 1-3%, 2-Ethylhexyl Salicylate8-10%, titanium dioxide 4-6%, alumina 1-3%, deionized water balance. The invention overcomes the problems in the prior art and provides an air cushion BB cream that can automatically adjust its own color according to the intensity of external light, has good color uniformity, light and thin concealer, and has multiple functions. 

Preparation of 2-Ethylhexyl Salicylate

The first step, in the methyl salicylate solution that purity is 70%-99.9%, add the isooctyl alcohol solution that purity is 70%-99.9%, and methyl salicylate and isooctyl alcohol in the methyl salicylate solution The molar ratio of isooctyl alcohol in the alcohol solution is 1:1 to 1:3, and stirred for 1 to 3 hours to form a uniformly mixed raw material solution.
As preferably, in the first step, the isooctyl alcohol mol ratio in the methyl salicylate solution and the isooctyl alcohol solution is 1:2.

In the second step, a solid inorganic base catalyst is added to the raw material solution prepared in the first step, and the mass of the inorganic base catalyst is 0.2%-1.0% of the mass of the raw material solution to form a reaction solution.
In the second step, the inorganic base catalyst is sodium hydroxide (NaOH) or potassium hydroxide (KOH). Preferably, the mass of the inorganic base catalyst is 0.5% of the total mass of the raw material solution.

In the third step, heat the reaction solution prepared in the second step to 100-200°C, and stir the reaction for 4-10 hours, then cool the reaction solution to 20°C to 80°C, and use hot water with a temperature of 50-100°C The reaction solution was washed, and the organic phase was separated and extracted.
In the second step, methanol is recovered after stirring the reaction for 4-10 hours. Heating the reaction solution to 100-200°C produces methanol gas. A recovery device is used to recover the methanol produced during the transesterification process between the inorganic alkali catalyst and the raw material solution. As preferably, the reaction solution is heated to 150°C. The stirring reaction time was 5 hours. The number of times of washing the reaction solution with hot water is two or three times.

The fourth step: first, add anhydrous Na2SO4 to the organic phase extracted in the third step, dry the organic phase with anhydrous Na2SO4, and remove the Na2SO4 in the organic phase after standing for 8-12 hours; then, remove the Na2SO4 organic Add the phase into the flask, carry out oil pump vacuum distillation, and collect the fraction at 174—178°C/1.0kPa, which is 2-Ethylhexyl Salicylate.
In the fourth step, oil pump vacuum distillation is a prior art. 174-178°C/1.0kPa means that the pressure gauge of the oil pump shows 1.0kPa, and the thermometer in the container containing the organic phase shows 174-178°C.

2-Ethylhexyl Salicylate This preparation has the Effect of

(1) The recovery rate of 2-Ethylhexyl Salicylate is high, and the purity is high. In the prior art, salicylic acid is used as a raw material and concentrated sulfuric acid is used as a catalyst for direct acidification to prepare isooctyl salicylate. The recovery rate of 2-Ethylhexyl Salicylate can reach 80-85%, and the purity can reach 90-95%. When sodium methoxide is used as a catalyst to prepare isooctyl salicylate through transesterification, in this method, the recovery rate of 2-Ethylhexyl Salicylate can reach 85%, and the purity can reach 98.5%. The recovery rate of isooctyl salicylate prepared by the preparation method of the present invention can reach more than 90%, and the purity can reach more than 99.0%. It can be seen that the 2-Ethylhexyl Salicylate prepared by the present invention has high recovery rate and high purity.

(2) The process is simple. The preparation method of the present invention takes methyl salicylate and isooctyl alcohol as raw materials, uses inorganic bases as catalysts, and prepares 2-Ethylhexyl Salicylate through transesterification. The whole process is simple and easy to realize in industry.

(3) The preparation cost is low and the economic benefit is high. Compared with the use of sodium methylate as a catalyst in the prior art, the present invention uses an inorganic base as a catalyst. The inorganic base is cheap, which is beneficial to reduce the preparation cost and improve the economic benefit. Simultaneously, adopt inorganic base as catalyst to prepare 2-Ethylhexyl Salicylate, the reaction temperature in the preparation process is relatively low, usually 100-200 ℃. And in the prior art, when using sodium methylate as a catalyst to prepare 2-Ethylhexyl Salicylate, the reaction temperature in the preparation process is usually above 200°C. The reaction temperature in the preparation process is lower, which is conducive to reducing the cost of industrial production.

(4) Methanol can be recycled, which is beneficial to environmental protection and improves economic benefits. The methanol produced by the transesterification process in the present invention can be recycled as a by-product. This is not only beneficial to environmental protection, but also has certain economic value.

About Products:
If you need 2-Ethylhexyl Salicylate this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of 2-Ethylhexyl Salicylate, ZSpharmac will provide 2-Ethylhexyl Salicylate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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