Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

2-Ethylhexyl 4-Dimethylaminobenzoate CAS 21245-02-3

Molecular Formula: C17H27NO2

Formula Weight: 277.4

ZSpharmac: 2-Ethylhexyl 4-Dimethylaminobenzoate Supplier Manufacturer

Product Name: 2-Ethylhexyl 4-Dimethylaminobenzoate
CAS No: 21245-02-3
Purity: 99%

Navigation Bar

Basic Info

Product Name:2-Ethylhexyl 4-Dimethylaminobenzoate
Other Names:Isooctyl P-Dimethylaminobenzoate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White to Orange Neat
EINECS No.:244-289-3
Provide:2-Ethylhexyl 4-Dimethylaminobenzoate MSDS;
2-Ethylhexyl 4-Dimethylaminobenzoate COA

What is 2-Ethylhexyl 4-Dimethylaminobenzoate?

The photoinitiator EHA (isooctyl p-dimethylaminobenzoate, trade name ESCALOL507) is a good UV absorber in the UVB region, as well as its optimum UV absorption height is 311nm (ethanol option). As an anti-ultraviolet active ingredient, it is widely utilized in sun block cosmetics abroad in significant amounts. The united state FDA notes sunscreen having this item ingredient as the first classification of suggested cosmetics. Currently, as my country’s sun block item market continues to create rapidly year by year, the raw material of isooctyl para-dimethylaminobenzoate (photoinitiator EHA) requires to be imported from abroad yearly to be used as an anti-aging agent for commercial products. For that reason, it is of terrific sensible relevance to perform research study on the synthesis procedure of isooctyl p-dimethylaminobenzoate (photoinitiator EHA), and also it will certainly likewise assist to realize the localization of the item.

2-Ethylhexyl 4-Dimethylaminobenzoate Property

Melting point 242.5-243.5 °C
Boiling point 325 °C (lit.)
density 0.995 g/mL at 25 °C (lit.)
vapor pressure 0.001Pa at 25℃
refractive index n20/D 1.542(lit.)
Fp >230 °F
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
form neat
Specific Gravity0.995
color Off-White to Orange
Water Solubility 100μg/L at 20℃


2-Ethylhexyl 4-Dimethylaminobenzoate Application

2-Ethylhexyl 4-Dimethylaminobenzoate is a kind of very efficient amine accelerator, made use of along with complimentary radical (II) kind photoinitiators. It is normally used for UV recovery of varnish completing systems theoretically, wood, steel and additionally plastic surface areas. It can also be used for It is also a fantastic sensitizer for the ultraviolet radiation polymerization response of singular or multiple monomers. It is normally made use of in combination with thioxanthone photoinitiators in addition to acetophenone photoinitiators, which can not just promote photoinitiation, however additionally It can effectively remove the disturbance of oxygen on photoinitiated polymerization. 2-Ethylhexyl 4-Dimethylaminobenzoate can be made use of as a superb anti-UV additive in addition to is frequently used in water resistant sun block cosmetics, containing isopentyl para-dimethylaminobenzoate (IADB) along with isooctyl para-dimethylaminobenzoate (photoinitiated Agent EHA) (EHA, trade name 507), the last is a wonderful ultraviolet absorber in the UVB area. As a sunscreen, it is generally taken advantage of globally. The united state FDA notes it as the preliminary classification advised for usage. Sunscreen. Para-dimethylaminobenzoate is not just used in the field of cosmetics, yet likewise can be used as a chemical, such as: methyl para-dimethylaminobenzoate, propyl para-dimethylaminobenzoate, n-butyl para-dimethylaminobenzoate Both its solutions have disinfectant residential or industrial buildings.

2-Ethylhexyl 4-Dimethylaminobenzoate Preparation

Using N, N-dimethyl p-aminobenzoic acid and isooctyl alcohol as basic materials, no solvent is required for dehydration, p-toluenesulfonic acid is utilized as the esterification catalyst, and a high negative pressure method is utilized to eliminate the water produced throughout the reaction, thereby making the favorable The response can proceed to the maximum degree, and also the response temperature level is managed at 110-120 ° C. The emphasis got on the esterification reaction conditions without solvent engagement: reaction temperature 110 ~ 120 ℃, vacuum cleaner degree -0.095 MPa, response time 6h, the molar ratio of p-dimethylaminobenzoic acid and also isooctyl alcohol is 1:3.5, and the molar proportion of p-dimethylaminobenzoic acid and isooctyl alcohol is 1:3.5. Based upon methylaminobenzoic acid, the item yield was 90%.

Step 1: Synthesis of p-dimethylaminobenzoic acid
Dissolve 149g (1mol) of p-dimethylaminobenzaldehyde in 600mL of toluene, maintain the system temperature level at 5-10 ° C, include 6.5 gKH2PO4 and 100mL of water, and include NaClO2 (1.35 mol, 122.2 g) and 1000mL of water dropwise while mixing to form a blend The liquid option is included dropwise in 1.5 hours, and after that kept warm for one more 3 hours. After stirring, the temperature is elevated to 25 ~ 30 ° C. React for another 3 hours and follow the response with TCL. Then 1000 mL of 10% NaOH remedy was contributed to the response combination. This alkaline liquid option was removed with chloroform (2 × 400mL, 1 × 200mL). The remaining liquid remedy was cooled down with an ice bath. Use 4 mol/L hydrochloric acid to adjust the pH value to 2 to 3, filter the solid obtained, wash with water and also ethanol, and completely dry to acquire 142 g of white strong, with a return of 86%. The melting point is 240 ~ 241.5 ℃ (recrystallized from ethanol), as well as the NMR range follows the standard spectrum.

Action 2: Synthesis of 2-Ethylhexyl 4-Dimethylaminobenzoate
Include 150g of homemade p-dimethylaminobenzoic acid, 525g of isooctyl alcohol and also 35g of p-toluenesulfonic acid into a 500mL three-necked flask, regulate the temperature level to 110 ~ 120 ° C, as well as perform an adverse pressure dehydration reaction for 6 hours. Great to area temperature level, include saturated seawater, mix, let stand and divide the organic stage, then include sodium hydroxide liquid remedy to clean up until neutral. After incorporating the water stages, include potassium carbonate remedy to clean till neutral, and make use of a percentage of oil ether to wash. Remove, integrate the natural stages, dry and eliminate the solvent over anhydrous magnesium sulfate, and after that boil down out the 2-Ethylhexyl 4-Dimethylaminobenzoate portion under decreased stress. The yield is 90%. The IR characterization outcomes are consistent with the item. The pre-distillation fraction is unreacted isooctyl alcohol, which can be reused. After the recurring fluid in the kettle is concentrated for healing of p-toluenesulfonic acid, a percentage of wastewater can be released in a conventional sewer treatment device to meet the requirements.

About Products:
If you need the cosmetic raw material 2-Ethylhexyl 4-Dimethylaminobenzoate, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of 2-Ethylhexyl 4-Dimethylaminobenzoate, our company, ZSpharmac will provide 2-Ethylhexyl 4-Dimethylaminobenzoate raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get 2-Ethylhexyl 4-Dimethylaminobenzoate Quotation