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2-Ethylhexanoic Acid CAS 149-57-5

Molecular Formula: C8H16O2

Formula Weight: 144.21

ZSpharmac: 2-Ethylhexanoic Acid Supplement

Product Name: 2-Ethylhexanoic Acid
CAS No: 149-57-5
Purity: 99%

Basic Info

Product Name:2-Ethylhexanoic Acid
Other Names:2-Ethylhexanoic Acid, 99%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Clear Liquid
EINECS No.:205-743-6
Storage:Store Below +30°C.
Provide:2-Ethylhexanoic Acid MSDS;
2-Ethylhexanoic Acid COA

What is 2-Ethylhexanoic Acid?

2-Ethylhexanoic Acid can be used as an intermediate for paint and coating driers, as a modifier for alkyd resins, as a catalyst for the production of peroxides as a catalyst for polymerization, and as a stabilizer for lubricating oil esters and PVC. It is widely used in the market.

2-Ethylhexanoic Acid Properties:

Melting point -59 °C
Boiling point 228 °C(lit.)
density 0.906
vapor density 4.98 (vs air)
vapor pressure <0.01 mm Hg ( 20 °C)
refractive index n20/D 1.425(lit.)
Fp 230 °F
storage temp. Store below +30°C.
solubility 1.4g/l
form Liquid
pkapK1:4.895 (25°C)
color Clear
OdorMild odour
PH3 (1.4g/l, H2O, 20℃)
PH Range3 at 1.4 g/l at 20 °C
explosive limit1.04%, 135°F
Water Solubility 2 g/L (20 ºC)


2-Ethylhexanoic Acid Uses

  1. 2-Ethylhexanoic Acid is mainly used to prepare various metal salts as driers for coatings and paints, and its esters can be used as plasticizers and raw materials for carbenicillin.
  2. Most of 2-ethylhexanoic acid is converted into salts of metal zirconium, cobalt, molybdenum, zinc, etc., which are used as paint driers and heat stabilizers for PVC plastics; tin salts are used as additives for plastic pipes; barium salts, cadmium salts Salts are used in plastic calendering products and stabilizers, 2-ethylhexanoic acid and its esters are also used in medicine, fungicides, metal lubricants, cosmetics, etc., and its glycerides are excellent plasticizers. 2-Ethylhexanoic acid is the raw material of the medicine carbenicillin.
  3. 2-Ethylhexanoic acid intermediate in paint and coating driers, used as alkyd resin modifier, in the production of peroxides as catalysts in polymerization reactions (eg PE), in lubricating oil esters and PVC stabilization agent.

Preparation of 2-Ethylhexanoic Acid

report one,
500g of isooctanol, 258g of potassium hydroxide, 10g of zinc formate were added successively to the 2000ml autoclave, the reaction kettle was replaced with nitrogen for 2 times to discharge the air in the system, and the reaction was carried out at 230 ° C and 2Mpa after sealing, and the reaction was carried out. After 6h, the temperature was kept for 50min, then the temperature was lowered to below 160°C, the pressure in the kettle was reduced to normal pressure, 400ml of distilled water was added, and the mixture was stirred for 30min to obtain 2-Ethylhexanoic Acid potassium aqueous solution.

Transfer the 2-Ethylhexanoic Acid potassium aqueous solution to the flask, slowly add 212 g of 94 wt% formic acid solution under stirring, control the reaction temperature to 60 ° C, react for 30 min, move to a separatory funnel, let stand for 30 min, and separate the water phase by layer and water. The phase is simply concentrated to obtain potassium formate solution (the solution can be directly sold as a commodity or concentrated into a certain concentration such as 74% for sale); the oil phase is washed twice with 60g distilled water to obtain thick 2-Ethylhexanoic Acid, and the unreacted alcohol is removed by distillation under reduced pressure. , 542g of isooctanoic acid finished product was obtained by rectification, the yield in terms of isooctanol was 108.4%, and the molar yield was 97.92%.

report two,
In a 2000ml autoclave, 250g of isooctanol, 172g of caustic soda, 1.6g of zinc acetate were added successively, and then 250g of isooctanol was added. The reaction kettle was filled with nitrogen, and the reaction was carried out at 250°C and 2.8MPa. After condensation, it was discharged to the outside. When no hydrogen was released in the reaction, the reaction was kept under pressure for 40 minutes, cooled to below 120 ° C, and then the pressure in the kettle was reduced to normal pressure, 500 ml of distilled water was added, and stirred for 30 minutes to obtain an aqueous solution of sodium isooctanoate.

Add 350g of distilled water to another flask, slowly add 250g of concentrated sulfuric acid under stirring, keep the temperature in the flask not more than 80°C, slowly pour the reactants in the autoclave into the flask, control the reaction temperature to be 70°C, react for 40min, move to Separation funnel, keep the temperature static for 1 hour, then remove the water phase by layers, and recover the refined sodium sulfate after the water phase treatment; the oil phase is washed twice with distilled water at about 70 °C to obtain crude isooctanoic acid, and the unreacted alcohol is distilled off under reduced pressure. , rectification to obtain 2-Ethylhexanoic Acid finished product, the yield is 105%.

The Mechanism of Action of 2-Ethylhexanoic Acid

A mouse model of anencephaly induced with sodium 2-ethylhexanoate (+ or -)-2-ethylhexanoate has been developed using a variety of administration regimes. Three consecutive administrations at half-day intervals, the most sensitive time for inducing extracerebral malformations is the 8th-9th day of pregnancy. Using racemic material, it was determined that the SWV strain was more susceptible to induction of anencephaly than the C57BL/6NCrlBR strain. The enantiomers of 2-ethylhexanoic acid were separated to greater than 99.8% optical purity by preparative HPLC and greater than 99% purity by gas chromatography analysis. The (R)-enantiomer has been shown to be a more potent teratogen than the (S)-enantiomer, inducing extracerebral malformations as well as malformations in other organ systems. Pharmacokinetic analyses of each enantiomer were performed in maternal plasma, maternal muscle and embryos. Pharmacokinetics indicated that the peak concentrations (Cmax) of the two enantiomers in the three compartments were approximately equal and were reached within 15 minutes after the third dose. The area under the concentration vs. time curve for both enantiomers of the (R)-enantiomer is approximately 10-fold higher because the elimination of this compound is somewhat slower. There is negligible (or no) racemization of the two enantiomers in biological samples. The results showed that the area under the enantiomeric tortuosity difference (R)-enantiomer was approximately 10-fold higher in the concentration versus time curve value for the two enantiomers, as this compound was slightly slower to eliminate. There is negligible (or no) racemization of the two enantiomers in biological samples. The results showed that the area under the enantiomeric tortuosity difference (R)-enantiomer was approximately 10-fold higher in the concentration versus time curve value for the two enantiomers, as this compound was slightly slower to eliminate. There is negligible (or no) racemization of the two enantiomers in biological samples. The results suggest that the aberrational differences in the enantiomers of sodium 2-ethylhexanoate are not due to differences in the concentrations of these enantiomers in the embryos, but are more likely due to specific interactions of the enantiomers with chiral molecules in the embryos. effect.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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