2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER CAS 94413-64-6

Molecular Formula: C8H6N2O2

Formula Weight: 162.15

ZSpharmac: 2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER Supplement

Product Name: 2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER

CAS No: 94413-64-6

Purity: 99%

Basic Info

Product Name:	2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER
Other Names:	Topiroxostat Impurity 15
CAS:	94413-64-6
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Pharmaceutical Intermediates
Appearance:	Pale Brown Solid
EINECS No.:	None
Storage:	Inert Atmosphere,Room Temperature
Provide:	2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER MSDS； 2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER COA

What is 2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER?

Methyl 2-cyano-4-pyridinecarboxylate is the intermediate of topicastat, white powder, slightly soluble, high purity, good stability, strong and lasting uric acid lowering effect, can be used for the treatment of chronic hyperuricemia gout .

2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER Properties:

Melting point	107-109℃
Boiling point	296.6±25.0 °C(Predicted)
density	1.25±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	-2.43±0.10(Predicted)
form	Solid
color	Pale brown
Water Solubility	Slightly Soluble in water (6.2 g/L) (25°C).

2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER Uses

Tobinostat is used for the treatment of chronic hyperuricemia in gout. Compared with the traditional drug allopurinol (purine analog), it will not affect the metabolism of purine and pyridine and the activity of its enzymes, and its effect of reducing uric acid is stronger. High-dose repeated administration is not required, and the safety is better, and methyl 2-cyano-4-pyridine carboxylate is an important raw material for synthesizing tobicistat.
Methyl 2-cyano-4-pyridinecarboxylate can be used in the synthesis of various pharmaceuticals and bioactive compounds, such as tetrasubstituted imidazolines, as potent and selective neuropeptide Y (NPY) Y5 receptor antagonists.

Preparation of Methyl 2-cyano-4-Pyridinecarboxylate

To a 250ml there-necked flask, add methylisonicotinic acid-N-oxide (15.31g, 0.1mol) and 200ml of acetonitrile and stir to dissolve completely, add triethylamine (15g, 0.15mol), trimethylsilicon cyanide (29.76g) , 0.3mmol), nitrogen protection reflux reaction for 20 hours, TLC detection reaction ends. The solvent was evaporated to dryness under reduced pressure, and the residue was subjected to silica gel column chromatography, eluted with dichloromethane-methanol (50:1), to obtain a yield of 13.48 g of white crystals, 83.14%. 1H NMR (600 MHz, DMSO-d6, δppm): 4.03(s,3H,), 8.11(d,1H,), 7.76(s,1H), 8.26(s,1H), 8.89(d,1H).

Purity Detection of Methyl 2-cyano-4-Pyridinecarboxylate

The impurities produced during the synthesis of methyl 2-cyano-4-pyridinecarboxylate mainly include methyl isonicotinate and methylisonicotinic acid N-oxide.

Methyl 2-cyano-4-pyridinecarboxylate and main impurity methyl isonicotinate are similar in polarity, CN201610560075.4 provides a kind of isocratic elution to realize methyl 2-cyano-4-pyridinecarboxylate and phase The adjacent impurity peaks can be completely separated, and the method with good peak shape can realize the accurate analysis of the content of methyl 2-cyano-4-pyridinecarboxylate. A high-performance liquid chromatography purity detection method for complete separation of methyl 2-cyano-4-pyridine carboxylate and its main impurities involved in the present invention comprises the following steps:

a. Preparation of the test solution: take methyl 2-cyano-4-pyridinecarboxylate, dissolve it with mobile phase or methanol, and prepare a solution with a concentration of 0.5mg/ml to 1.2mg/ml as the test solution .

b. Preparation of impurity reference solution: take methyl isonicotinate and methylisonicotinic acid N-oxide, dissolve with mobile phase or methanol, and prepare a solution with a concentration of 0.5mg/ml ~ 1.2mg/ml as impurities reference solution.

c. Use high performance liquid chromatography to detect the test solution and the impurity reference solution respectively. The detection conditions are: the chromatographic column is a C18 column; the mobile phase is methanol-buffer salt, and the volume ratio of methanol to the buffer solution is 10%: 90%～90%: 10%; the injection volume is 20ul, the flow rate is 0.5ml/min～1.5ml/min; the column temperature is 10℃～40℃; the detection wavelength is 200nm～300mn.

d. Calculate the peak areas of methyl isonicotinate and methylisonicotinic acid N-oxide according to the peak area normalization method.

GHS label Elements, Including Precautionary Statements

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Signal word Warning
Hazard statement
H302 Harmful if swallowed
H312 Harmful in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H332 Harmful if inhaled
H335 May cause respiratory irritation
Precautionary Statements
prevention
P264 Wash thoroughly after handling….
P270 Do not eat, drink or smoke while using this product.
P280 Put on protective gloves/protective clothing/eye protection/face protection/ear security/ …
P261 Avoid breathing dust/mist/gas/mist/vapour/spray.
Reply
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/…
P317 Get medical help.
P321 Special Handling (see… on this label).
P362+P364 Remove contaminated clothing and wash before reuse.
P332+P317 If skin irritation occurs: Get medical help.
P304+ P340 IF BREATHED IN: Get rid of person to fresh air and also maintain
P319 Obtain medical help if you really feel weak.
storage
Store P403+P233 in a well-ventilated place. Keep container tightly closed.
P405 Store locked.
deal with
P501 Dispose of contents/container to an appropriate handling and disposal facility in accordance with applicable laws and regulations and product characteristics at the time of disposal.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION

Help China Chemicals to benefit the happiness of human life

OUR VISION

Become the most trusted chemical supplier in the world

OUR BUSINESS PHILOSOPHY

Striver – oriented, enrich employees, customer first, deep service, seek development

OUR VALUES

Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.