2-Butene-1,4-Diol CAS 110-64-5

2-Butene-1,4-Diol can be used as an intermediate in organic synthesis and medicinal chemistry, and is mostly used in the synthesis of fine chemicals and bioactive molecules. For example, 1,4-butenediol is an important raw material in the synthesis of vitamin B6 and has important application value. Vitamin B6, also known as pyridoxine, is an important water-soluble vitamin that plays an important role in the growth and development of the human body, the nervous system, and the immune system. Its chemical structure contains benzene rings and pyrazine rings, while 2- Butene-1,4-Diol is an important intermediate in the synthesis of vitamin B6. Application of 2-Butene-1,4-Diol

Figure 1 Application of 1,4-butenediol

Sodium hydride (3.27 g, 60% in oil, 81.2 mmol) and tetrahydrofuran were added to a dry reaction flask, and then 1,4-butenediol (3.0 g, 3.4 mmol) was slowly added to the reaction mixture. When the reaction will obviously evolve gas, be careful to balance the pressure change in the reaction. The resulting reaction mixture was stirred at room temperature for several hours, then a solution of methyl iodide (10.6 mL, 170 mmol) in tetrahydrofuran (60 mL) was added, the mixture was stirred at 0°C for 10 min, then the cooling bath was removed and placed in Stir at 25°C for 24 h. After the reaction, the reaction mixture was slowly poured into 60 mL of brine, and then extracted with ether (3 × 50 mL). The combined organic layers were dried with anhydrous magnesium sulfate, the desiccant was removed by filtration and the obtained filtrate was concentrated to obtain a colorless oil, and the pure target product was obtained by distillation under reduced pressure.