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2-Amino-2-Methyl-1-Propanol CAS 124-68-5

Molecular Formula: C4H11NO

Formula Weight: 89.14

ZSphaemac: 2-Amino-2-Methyl-1-Propanol Supplement

Product Name: 2-Amino-2-Methyl-1-Propanol
CAS No: 124-68-5
Purity: 99%

Basic Info

Product Name:2-Amino-2-Methyl-1-Propanol
Other Names:2-Amino-2-Methyl-1-Propanol(AMP-95)
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Colorless Liquid
EINECS No.:204-709-8
Storage:Store Below +30°C.
Provide:2-Amino-2-Methyl-1-Propanol MSDS;
2-Amino-2-Methyl-1-Propanol COA

What is 2-Amino-2-Methyl-1-Propanol?

2-Amino-2-methyl-1-propanol is abbreviated as AMP. It is a multifunctional auxiliary for the preparation of environmentally friendly latex paints. It can also be used as organic bases and pharmaceutical intermediates for other neutralization and buffering purposes, such as biochemical diagnostic reagents. Buffer and Activator. 2-Amino-2-methyl-1-propanol enhances and strengthens many coating components and enhances the action and performance of other additives. AMP can improve the scrub resistance, hiding power, viscosity stability and color development of coatings. The addition of replacing ammonia in the paint can provide many advantages such as: reducing system odor, reducing corrosion and flash rust in the tank.

2-Amino-2-Methyl-1-Propanol Properties:

Melting point 24-28 °C (lit.)
Boiling point 165 °C (lit.)
density 0.934 g/mL at 25 °C (lit.)
vapor density 3 (vs air)
vapor pressure <1 mm Hg ( 25 °C)
refractive index n20/D 1.4455(lit.)
Fp 153 °F
storage temp. Store below +30°C.
solubility H2O: 0.1 M at 20 °C, clear, colorless
form Low Melting Solid
color Colorless
Specific Gravity0.934
PH11.0-12.0 (25℃, 0.1M in H2O)
PH Range9.0 – 10.5
pka9.7(at 25℃)
Water Solubility miscible


2-Amino-2-Methyl-1-Propanol Uses

  1. 2-Amino-2-methyl-1-propanol and carboxylic acid compounds form derivatives for gas chromatographic analysis. Synthesis of Surfactants. Vulcanization accelerator. Acid gas absorbent. Additives for coatings and latex paints, as well as pigment dispersion, pH adjustment and rust prevention.
  2. 2-Amino-2-methyl-1-propanol is mainly used as a biostabilizer and pH stabilizer in the metal processing field. This product is widely used in the concentrate and post-treatment of metalworking fluids in Europe and the United States, and is the main raw material for the development of biostable formulations. It is used to increase and stabilize the pH value in on-site replenishment to save and extend the life of metalworking fluids. The product also has the advantages of preventing cobalt precipitation and low foaming. Used in synthetic surfactants; vulcanization accelerators; acid gas absorbents.

Production Method of 2-Amino-2-Methyl-1-Propanol

The 2-nitropropane was reacted with aqueous formaldehyde, then concentrated to 70% 2-methyl-2-nitro-1-propanol in water. Dilute to 30% with methanol. Put it into an autoclave, add 5% of nitrous skeleton nickel by weight, hydrogenation reduction at 30°C and 267 atmospheres for 6-8h. After the methanol and most of the water were distilled off under normal pressure, the distillation was performed under reduced pressure, and the fraction at 103°C (8.53-8.67kPa) was collected, which was 2-amino-2-methyl-1-propanol. Based on 2-nitropropane, the yield was 70.5%.

Preparation of 2-Methyl-2-Nitro-1-Propanol

The production process of 2-amino-2-methyl-1-propanol in foreign countries is synthesized from 2-nitropropane, such as Angus in the United States and AMP-95 of Dow Company, which can convert 2-nitropropane into 2-nitropropane. Propane is first reacted with formaldehyde for formylation, then the nitro group is reduced, and then 2-amino-2-methyl-1-propanol is obtained by separation. The synthetic route using 2-nitropropane as a raw material has its shortcomings, the raw material is dangerous, it is not easy to store and transport, the investment in production equipment is large, and it is difficult to prepare high-purity 2-amino-2-methyl-1-propanol.
Method 1. In order to solve the problems in the prior art that the raw materials for 2-amino-2-methyl-1-propanol are dangerous, the production investment is large, and the products are not easy to purify, CN200610053023.4 provides a kind of raw materials that are easy to obtain and cost effective. The preparation method of amino-2-methyl-1-propanol with low content and easy product purification.
A 500ml glass tube reactor was charged with 205.5g of acetonitrile (5mol), the two ports of the reaction flask were connected to bottom tubes, one was connected to the chlorine gas source, the other was connected to the isobutylene source, the other port was installed with a thermometer, and the reaction flask was placed Put into a 0°C ice-water bath, start magnetic stirring, and when the temperature of the system drops to 0°C, 63.8 g (0.9 mol) of chlorine and 50.5 g (0.9 mol) of isobutene are introduced into the reaction flask in the same proportion. Continue to stir for half an hour after aeration, then dropwise add 11 g of water (0.6 mol), stir for half an hour after dropwise addition, then filter, and vacuum the filtrate at about 45°C to obtain 83 g of a yellowish concentrated solution. Dissolve the concentrated solution obtained in the previous step with 41.5g of ethanol solution with a volume concentration of 95%, heat and stir until reflux, then add 29.05g of concentrated hydrochloric acid with a weight concentration of 37%, heat under reflux for about 2 hours, and then distill the system while heating. Add water, ethanol and ethyl acetate in the ethanol solution, add 41.5 g of ethanol solution and 12.45 g of concentrated hydrochloric acid, and continue to reflux for about 2 hours, distill out the solvent while heating, add water to the concentrate and vacuum distillation until there is no more distillate. , the obtained 66g viscous white solid is the hydrochloride of AMP.
The white AMP hydrochloride intermediate obtained in the previous step was neutralized with 55 g of sodium hydroxide solution with a mass concentration of 40% until pH=12, the water in the system was distilled off under reduced pressure, and then extracted with an ethanol solution with a volume concentration of 95%, and filtered. , the filtrate was evaporated to ethanol under reduced pressure to obtain 40 g of amp crude product, and the yield to isobutene was 50%. The obtained crude 2-amino-2-methyl-1-propanol is subjected to rectification to prepare a high-purity product, the content of which is greater than or equal to 99%.
Method two, CN201510712516.3 reported a kind of method of synthesizing 2-amino-2-methyl-1-propanol by isopropylamine, described isopropylamine and synthesis gas in the presence of metal catalyst, ligand and solvent , and the 2-amino-2-methyl-1-propanol is obtained by reacting at 100-200° C. and 0.8-20 MPa.
Get diphenyl ether 300g, isopropylamine 30g (0.51mol), palladium acetate 11.25g (50mmol) and triphenylphosphine 65.5g (250mmol), join successively in the 1000mL autoclave, the synthesis gas is passed into the autoclave When the pressure was 3MPa, the synthesis gas was a mixture of H2 and CO with a molar ratio of 1:1, and the stirring was started and the temperature was raised to 140 °C. When the temperature rose to 140°C, the pressure was supplemented with synthesis gas to 8MPa to start the timing reaction. During the reaction, the syngas pressure was supplemented intermittently to maintain the reaction pressure at 7-8 MPa. Gas chromatographic tracking found that isopropylamine was no longer converted in 6h, and the reaction was stopped by cooling at this time.
The reaction solution was taken out, distilled under reduced pressure at 2.5 kPa, and the fractions between 68 and 72°C were collected to obtain 40.85 g of pure 2-amino-2-methyl-1-propanol with a yield of 90%. At the same time, 422 g of distillation still residue was obtained.
The spectral data of pure 2-amino-2-methyl-1-propanol are as follows:
1H NMR (300 MHz, CDCl3, TMS as internal standard): 3.27 (s, 2H, -CH2-), 2.60 (brs, 3H, -OH, -NH2), 1.09 (s, 6H, CH3-).
FT-IR (KBr, σ/cm-1): 3340 (N-H st and O-H st), 2966 (C-H st), 1595 (N-Hδ), 1380 (C-Hδ), 1310 (C-N st), 1068 ( C-O st).

Fig. 1 is the hydrogen nuclear magnetic spectrum of pure 2-amino-2-methyl-1-propanol;

Figure 2 is the infrared spectrum of pure 2-amino-2-methyl-1-propanol.

Other Applications of 2-Amino-2-Methyl-1-Propanol

CN200610028459.8 reported an improved preparation method of water-free hand sanitizer. The components are assembled according to the following steps:
(1) The carbomer and deionized water are stirred and heated in a vacuum worm gear mixer at 40~45°C until completely dispersed; then cool down, add ethanol and stir and mix; then add 2-amino-2-methyl-1- Propanol; this A-phase reactant rotates rapidly with the blades of the vacuum turbine mixer.
(2) In another mixer, add triclosan to propylene glycol to fully dissolve, and become the B-phase reactant; pour the B-phase reactant into the A-phase reactant and mix. (3) Then slow down the speed of the vacuum turbine mixer, add glycerin and mix to form a C-phase product; take out the C-phase product from the machine at room temperature. According to the preparation method of the improved water-free hand sanitizer of the present invention, the preparation process and the preparation process are simple. The improved water-free hand sanitizer prepared by the preparation method of the present invention is an updated product, which has little inflammation to the skin, mild impact, strong detergency, and also plays the duty of disinfection as well as sanitation.
CN200810158538.X reports a waterproof aerosol sunscreen and its preparation method. Methyl acid, cyclomethicone, tocopheryl acetate and dimethyl ether are mixed in a certain proportion. Each sunscreen contains special denatured ethanol 40%~45%, 2-amino-2-methyl-1-propanol 0.35%~0.5%, octyl methoxycinnamate 7.5%~10%, aminoaniline Methyl ester 4%~6%, cyclomethicone 3%~4%, tocopheryl acetate 0.5%~0.8%, dimethyl ether 30%~35%, and the balance is deionized water. Special denatured ethanol is combined with 2-amino-2-methyl-1-propanol and mixed until complete. Add the other components except dimethyl ether. Continue mixing until complete. Filter and add dimethyl ether to fill. Can be applied directly to the face, absorbs UV rays, prevents skin from sunburn, and resists scouring of large amounts of water.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Business Philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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