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2-Acetylbutyrolactone CAS 517-23-7

Molecular Formula: C6H8O3

Formula Weight: 128.13

ZSpharmac: 2-Acetylbutyrolactone Supplement


Basic Info

Product Name:2-Acetylbutyrolactone
Other Names:Acetylbutyrolactone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Clear Liquid
EINECS No.:208-235-2
Storage:Keep in Dark Place,Sealed in Dry,Room Temperature
Provide:2-Acetylbutyrolactone MSDS;
2-Acetylbutyrolactone COA
Product Name: 2-Acetylbutyrolactone
CAS No: 517-23-7
Purity: 99%

What is 2-Acetylbutyrolactone?

Alpa-acetyl-gama-butyl ester, also known as 2-Acetylbutyrolactone, is an important organic chemical raw material, an intermediate for the preparation of chlorophyll, and can also be used in the pharmaceutical industry to manufacture anti-angina pectoris drugs. The raw materials for the preparation of vitamin B1 can also be used to synthesize 3,4-disubstituted pyridine and 5-(β-hydroxyethyl)-4-methylthiazole, which are widely used.

Light liquid with an ester-like odor. Melting point -12 to -13 ° C, boiling point 142-143 ° C(4kPa), 107-108 ° C (667Pa), 96 ° C(0.4 kPa), family member thickness 1.1846 (20/4 ° C), refractive index 1.4562, flash point 110 ° C. The solubility in water is 20% (quantity), as well as the solubility of water in this item is 12% (quantity). The service is blue to light blue-purple when in contact with iron.

2-Acetylbutyrolactone Properties:

Melting point <25 °C
Boiling point 107-108 °C5 mm Hg(lit.)
density 1.19 g/mL at 25 °C(lit.)
refractive index n20/D 1.459(lit.)
Fp >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 200g/l
form Liquid
color Clear
Water Solubility 310 g/L (20 ºC)


2-Acetylbutyrolactone Uses

1.2-Acetylbutyrolactone is used in the manufacture of drugs such as vitamin B1 and delaying pain.

2.2-Acetylbutyrolactone is mainly used as an intermediate in the manufacture of vitamin B1.

2-Acetylbutyrolactone Synthesis Device and Method

Fig. 1 is the structural representation of the utility model alpa-acetyl-gama-butyl ester synthesis device. In the figure, 1, the reaction kettle, 2, the condenser, 3, the upper tank, 4, the first pump, 5, the extraction kettle, 6, the second pump, 7, the rectifying tower, 8, the valve.
The ratio of γ-butyrolactone and methyl acetate of 1:1.5-1.8 is added into the reactor 1, and the 30% sodium methoxide liquid equivalent to 3 equivalents of γ-butyrolactone is pumped into the upper tank 3 through a pump, Start stirring, pass the steam into the heating jacket of the reaction kettle 1 and start heating, when heated to the beginning of reflux, start to drip the sodium methoxide liquid, adjust the steam amount and the speed of dripping so that the reaction is maintained at the temperature of micro-reflux, dripping. After adding, the heat preservation reaction is performed for 5-6 hours, the volatilized steam is cooled and refluxed into the reactor 1 through the condenser 2, and the uncooled gas enters the gas absorption device through the upper outlet of the condenser 2 to minimize the overflow of the waste gas. . After completion of the reaction, the sodium salt of alpa-acetyl-gama-butyl ester is obtained. The acetic acid solution is pumped into the upper tank 3, and the solution after the reaction in the reactor 1 is added dropwise by the upper tank 3, and the pH value of the adjustment solution is 5-6 to obtain the crude product of alpa-acetyl-gama-butyl ester. The crude product of the product is concentrated by distillation in the reactor 1, and a part of the excess solvent is removed. The obtained crude product is transferred to the extraction kettle 5 through the first pump 4, and the dichloromethane extractant is added to the extraction kettle 5, stirred for 1-2 h, and then the layers are statically separated, and the organic layer is transferred to the rectification distillation through the second pump 6. In the tower 7, the dichloromethane extractant is added again to the aqueous phase layer, so that the extraction is performed three times to reduce product loss, and the three extraction phases are combined to enter the rectifying tower rectification product, and other fractions obtained by rectification are passed through the liquid storage tank. Collect and recycle into production.

2-Acetylbutyrolactone Preparation and Production Method


CN200910144739.9 discloses a preparation method of cyclopropyl methyl ketone and bicyclopropyl ketone. The distillation residue of alpa-acetyl-gama-butyl ester is chlorinated with hydrochloric acid, and then cyclized and reacted with liquid caustic soda. , obtain the crude product of the organic layer cyclopropyl methyl ketone, then carry out distillation to obtain the cyclopropyl methyl ketone product; then react the remaining raffinate of the reaction with liquid caustic soda to obtain the crude product of bicyclopropyl ketone, then distill to obtain the bicyclopropyl ketone product Propyl ketone products.

The method adopts the distillation residue of alpa-acetyl-gama-butyl ester as raw material, reduces production cost, achieves waste recycling and environmental protection, conforms to the circular economy method strongly advocated by the state, and at the same time, the preparation method is simple, and the prepared product High purity.

Production Method:

1. γ-Butyrolactone and vinyl acetate obtained by Claisen condensation. 2. It is obtained by the condensation of ethyl acetoacetate (or methyl acetoacetate) with ethylene oxide and ring closure. In Japan, method 1 was used to produce, and the yield was slightly higher than that of method (2), but metal sodium was needed, and there were safety problems. In 1965, method 2 was used for production. The technological process of method 2 is as follows: ethylene oxide is added to a mixture of sodium hydroxide, water and ethanol that has been pre-cooled to below 0°C, and ethyl acetoacetate is added dropwise, and the reaction temperature is maintained at about 0°C. After dripping, continue to keep stirring for 5-6 hours, keep overnight, keep stirring at 0-3 °C for 8 hours the next day, and then keep overnight. On the third day, neutralize with acetic acid to pH = 8, and pump with chloroform (or benzene) in four times. Extract, combine each extraction liquid, recover chloroform (or benzene) at normal pressure, after ethanol, then fractional distillation under reduced pressure, above 85°C/5333Pa is low boiler (mainly ethyl acetoacetate), 100°C/400-667Pa The above is γ-acetylbutyrolactone, the average yield is nearly 60%, and the crude product content is about 90%.

2-Acetylbutyrolactone Supplement Hazard Identification

GHS Risk Statements H315 (98.47%): Causes skin inflammation [advising skin corrosion/irritation] H319 (99.69%): Causes severe eye irritation [WARNING Major eye damage/eye inflammation] H335 (96.33%): Might create respiratory irritation [Caution Details target body organ poisoning, single direct exposure; respiratory irritability] precautionary statement code P261, P264, P264+ P265, P271, P280, P302+ P352, P304+ P340, P305+ P351+ P338, P319, P321, P332+ P317, P337+ P317, P362+ P364, P403+ P233, P405 as well as P501 (The matching statement for each P-code can be discovered on the GHS category page.) ECHA C&L Notification Recap Aggregated GHS info given by 328 business to the ECHA C&L List from 15 alerts. Each alert might be related to multiple business. 1 out of 328 companies reported not fulfilling the GHS danger standards. For even more details, check out the ECHA C&L website. In 14 notifications given by 327 of the 328 business, there are hazard statement codes. Info might vary between alerts relying on contaminations, additives as well as various other aspects. Portion worths in parentheses represent the alert classification rate for firms that offer hazard codes. Only threat codes with a percentage worth above 10% are presented. 171 words (Less than 1 page).

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Buseniss Philososphy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our VaLeds
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to figh

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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