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2 2 4 4 Tetrahydroxybenzophenone CAS 131-55-5

Molecular Formula: C13H10O5

Formula Weight: 246.22

ZSpharmac: 2 2 4 4 Tetrahydroxybenzophenone Supplier

Product Name: 2 2 4 4 Tetrahydroxybenzophenone
CAS No: 131-55-5
Purity: 99%

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Basic Info

Product Name:2 2 4 4 Tetrahydroxybenzophenone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:205-028-9
Storage:Room Temperature
Provide:2 2 4 4 Tetrahydroxybenzophenone MSDS;
2 2 4 4 Tetrahydroxybenzophenone COA

What is 2 2 4 4 Tetrahydroxybenzophenone?

2,2′,4,4′-Tetrahydroxybenzophenone UV absorber comes from the series of benzophenone UV absorbers, the absorption wavelength variety is 320-400nm, it has a symmetrical benzene ring and hydroxyl groups on both sides, its thermal and photochemical properties are steady, all superior to BP-1 (UV-O), extensively made use of in plastics, materials, coatings, artificial rubber, photosensitive products as well as cosmetics markets, as well as its application on fabrics has been preferred by the fabric sector in the last few years Interest, the scope is getting wider and also bigger.

2 2 4 4 Tetrahydroxybenzophenone Property

Melting point 198-200 °C(lit.)
Boiling point 349.21°C (rough estimate)
density 1.216
refractive index 1.4825 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly, Sonicated), Methanol (Slightly)
form Solid
color Needles from H2O
Water Solubility Slightly soluble in water.


2 2 4 4 Tetrahydroxybenzophenone Uses

  1. 2 2 4 4 Tetrahydroxybenzophenone is used as pharmaceutical intermediate, photosensitive material, cosmetic anti-ultraviolet additive, etc.

2 2 4 4 The Preparation Method of Tetrahydroxybenzophenone

2 , 4 – Dihydroxybenzoic acid and resorcinol generate 2 2 4 4 Tetrahydroxybenzophenone under the action of a catalyst (the reaction formula is as follows), which is a typical C-acylation reaction. C-acylation reaction is an important method for the preparation of aromatic ketones. It is an electrophilic substitution reaction that introduces acyl groups on aromatic hydrocarbons and their derivatives. It belongs to an important category of Friedel-Crafts reactions. Lewis acids or protonic acids must be added to the reaction. Catalyst to enhance the electrophilic ability of the acylating agent, so that the reaction can proceed smoothly. The commonly used acylating agents for C-acylation reactions are acid halides and acid anhydrides, followed by carboxylic acids. The catalyst can be BF3, ZnCl2 and other Lewis acids and concentrated H2SO4, H3PO4 polyphosphoric acid and other protonic acids. Its function is to enhance the positive charge on the acyl carbon atom and improve the electrophilic reaction ability of the attacking reagent.

In a 150 mL three-neck flask equipped with a stirrer and a hydrogen chloride absorption system, put 1510 g (0114 mol) of resorcinol, 1514 g (011 mol) of 2,4-dihydroxybenzoic acid, 2015 g (0115 mol) of anhydrous ZnCl2 mol), POCl3 3010 g (0.120 mol) and solvent cyclobutane 15 mL, start stirring, mix the materials evenly, heat up to 70 ℃ ~ 75 ℃, keep warm for 2 h, until little hydrogen chloride gas is released in the absorption system. Then slowly add water to the reaction bottle, stir until it is completely dissolved, then pour it into 800 mL of cold water, and fully dissolve. The above solution was left to stand for 30 min, cooled to below 20 °C, filtered with suction and washed with water to obtain the crude product. Then the crude product was dissolved in hot water, treated with activated carbon, boiled for 30 min, hot filtered, cooled, a large number of light yellow crystals were precipitated, filtered with suction, washed and dried to obtain 1617 g of yellow crystal product, yield 6719%, mp 198 °C ~ 200 °C. IR: υmax (cm- 1) :3 350~3 200 (b, s, υO – H), 1 629 (s, υC = O), 1 590 – 1 450 (s, υbenzene ring), 850~650 (s ,δ benzene ring-H).

The ultraviolet absorber 2,2′,4-trihydroxybenzophenone was synthesized by using resorcinol, o-hydroxybenzoic acid and oxytrichloride as raw materials, sulfolane as solvent and anhydrous zinc chloride as catalyst. Investigation The effects of reaction temperature, catalyst and material ratio on the reaction were studied. The results showed that the optimum conditions for the synthesis reaction were: reaction temperature 70-75℃, material ratio n(resorcinol):n(o-hydroxybenzoic acid ) was 1:0.81, the amount of POCl3 was 19 mL, and the anhydrous zinc chloride was 23 g. Under these conditions, a red powder solid was obtained, with a melting point of 188-190°C and a yield of more than 88%. The product passed elemental analysis, Infrared spectra were characterized.

Production Process of Ultraviolet Absorber BP-2

The production process of BP-2 is fixed and the production capacity is low. There has been no great improvement in the past ten years. The material will cause the disproportionation of the whole reaction, and it is very difficult to improve. In addition, BP-2 production consumes a lot of water, about 96 tons of water is used to produce 1 ton of qualified BP-2 products, and the water after hydrolysis is difficult to handle, which is also the reason for affecting the production capacity of BP-2. In addition, due to the limited ability of the solvent sulfolane to dissolve BP-2, the existing process itself has the risk of curing. In order to avoid curing, the actual reaction temperature of the workers is often lower than the optimal reaction temperature during the limited 2.5hr effective reaction time, resulting in the failure of the reaction. Finish. In addition, after the hydrolysis is changed from dropwise to one-time transfer, the hydrolysis reaction is not complete. Although the reaction conversion rate can still reach 75%, the actual yield is difficult to exceed 62%. Therefore, BP-2 process improvement is necessary.

CN111320534A discloses a kind of production method of ultraviolet absorber BP-2, is characterized in that, specifically comprises the following steps:

S1: One reaction: Add dichloroethane and sulfolane in sequence to the reactor, stir to dissolve, open the vacuum valve of the reactor and put in 2-4-hydroxybenzoic acid and resorcinol again from the feeding port of the reactor, and turn off the vacuum Valve, open the tail gas absorption system, the reactor heats up to steam a part of dichloroethane, and cools down;

S2: Secondary reaction: After cooling down, open the vacuum valve of the reactor and put phosphorus oxychloride, anhydrous zinc chloride, and phosphorus trichloride into the reactor, close the vacuum valve, open the tail gas absorption system, and heat up the reactor. Insulation reaction, followed by cooling;

S3: Hydrolysis: add water to the reaction product in S2, heat up and stir to fully hydrolyze, heat up again until most of the dichloroethane overflows, and cool down;

S4: Prepare the crude product of BP-2: transfer the product obtained in S3 to the hydrolysis cooling kettle for cooling, and filter with suction to obtain the crude product of ultraviolet absorber BP-2;

S5: preparing BP-2 fine product: dissolving, decolorizing, filtering and crystallizing the crude product in S4 to obtain the ultraviolet absorber BP-2 fine product.

About Products:
If you need 2 2 4 4 Tetrahydroxybenzophenone as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of 2 2 4 4 Tetrahydroxybenzophenone, ZSpharmac will provide 2 2 4 4 Tetrahydroxybenzophenone raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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