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Zhishang Chemical

2 2 4 4 Tetrahydroxybenzophenone CAS 131-55-5

Molecular Formula: C13H10O5

Formula Weight: 246.22

ZSpharmac: 2 2 4 4 Tetrahydroxybenzophenone Supplier

Product Name: 2 2 4 4 Tetrahydroxybenzophenone
CAS No: 131-55-5
Purity: 99%

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Basic Info

Product Name:2 2 4 4 Tetrahydroxybenzophenone
Other Names:BP-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Needles From H2O
EINECS No.:205-028-9
Storage:Sealed in Dry,Room Temperature
Provide:2 2 4 4 Tetrahydroxybenzophenone MSDS;
2 2 4 4 Tetrahydroxybenzophenone COA

What is 2 2 4 4 Tetrahydroxybenzophenone?

2 2 4 4 Tetrahydroxybenzophenone is a high-efficiency water-soluble UV absorber, belonging to a series of benzophenone UV absorbers, widely used in plastics, resins, coatings, synthetic rubber, photosensitive materials and cosmetics industries. As the destruction of the earth’s ozone layer becomes more and more serious, the radiation of the sun’s ultraviolet rays on the earth becomes more and more intense. Therefore, ultraviolet absorbers are one of the essential additives for various polymer materials and skin protection products. There are few domestic reports on the synthesis of 2 2 4 4 Tetrahydroxybenzophenone, so the research on the synthesis process of polyhydroxybenzophenone will have great theoretical guiding significance and practical application value for the development and application of its downstream products.

2 2 4 4 Tetrahydroxybenzophenone Property

Melting point 198-200 °C(lit.)
Boiling point 349.21°C (rough estimate)
density 1.216
refractive index 1.4825 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly, Sonicated), Methanol (Slightly)
form Solid
color Needles from H2O
Water Solubility Slightly soluble in water.


2 2 4 4 Tetrahydroxybenzophenone Reaction Principle

2 , 4 – Dihydroxybenzoic acid and resorcinol generate 2 2 4 4 Tetrahydroxybenzophenone under the action of a catalyst (the reaction formula is as follows), which is a typical C-acylation reaction. C-acylation reaction is an important method for the preparation of aromatic ketones. It is an electrophilic substitution reaction that introduces acyl groups on aromatic hydrocarbons and their derivatives. It belongs to an important category of Friedel-Crafts reactions. Lewis acids or protonic acids must be added to the reaction. Catalyst to enhance the electrophilic ability of the acylating agent, so that the reaction can proceed smoothly. The commonly used acylating agents for C-acylation reactions are acid halides and acid anhydrides, followed by carboxylic acids. The catalyst can be BF3, ZnCl2 and other Lewis acids and concentrated H2SO4, H3PO4 polyphosphoric acid and other protonic acids. Its function is to enhance the positive charge on the acyl carbon atom and improve the electrophilic reaction ability of the attacking reagent.

2 2 4 4 Tetrahydroxybenzophenone Preparation Method

In a 150 mL three-neck flask equipped with a stirrer and a hydrogen chloride absorption system, put 1510 g (0114 mol) of resorcinol, 1514 g (011 mol) of 2,4-dihydroxybenzoic acid, 2015 g (0115 mol) of anhydrous ZnCl2 mol), POCl3 3010 g (0.120 mol) and solvent cyclobutane 15 mL, start stirring, mix the materials evenly, heat up to 70 ℃ ~ 75 ℃, keep warm for 2 h, until little hydrogen chloride gas is released in the absorption system. Then slowly add water to the reaction bottle, stir until it is completely dissolved, then pour it into 800 mL of cold water, and fully dissolve. The above solution was left to stand for 30 min, cooled to below 20 °C, filtered with suction and washed with water to obtain the crude product. Then the crude product was dissolved in hot water, treated with activated carbon, boiled for 30 min, hot filtered, cooled, a large number of light yellow crystals were precipitated, filtered with suction, washed and dried to obtain 1617 g of yellow crystal product, yield 6719%, mp 198 °C ~ 200 °C. IR: υmax (cm- 1) :3 350~3 200 (b, s, υO – H), 1 629 (s, υC = O), 1 590 – 1 450 (s, υbenzene ring), 850~650 (s ,δ benzene ring-H).

2 2 4 4 Tetrahydroxybenzophenone Preparation Raw Materials

The ultraviolet absorber 2,2′,4-trihydroxybenzophenone was synthesized by using resorcinol, o-hydroxybenzoic acid and oxytrichloride as raw materials, sulfolane as solvent and anhydrous zinc chloride as catalyst. Investigation The effects of reaction temperature, catalyst and material ratio on the reaction were studied. The results showed that the optimum conditions for the synthesis reaction were: reaction temperature 70-75℃, material ratio n(resorcinol):n(o-hydroxybenzoic acid ) was 1:0.81, the amount of POCl3 was 19 mL, and the anhydrous zinc chloride was 23 g. Under these conditions, a red powder solid was obtained, with a melting point of 188-190°C and a yield of more than 88%. The product passed elemental analysis, Infrared spectra were characterized.

2 2 4 4 Tetrahydroxybenzophenone Ecological Information

2 2 4 4 The manufacturing and also use Tetrahydroxybenzophenone in cosmetics and also personal treatment items, as a masking agent and UV absorber, along with in plastics, paints and car care products, may lead to its launch to the atmosphere via various waste streams. If launched to air, the estimated vapor pressure at 25 ° C is 1.6X10-11 mmHg, indicating that 2 2 4 4 Tetrahydroxybenzophenone will just exist in the particle stage in the atmosphere. The particle phase benzophenone 2 will be gotten rid of from the atmosphere by damp as well as dry deposition. 2 2 4 4 Tetrahydroxybenzophenone absorbs UV light at a wavelength of around 350 nm as well as a result may be vulnerable to photolysis by direct sunshine. If launched right into dirt, benzophenone-2 is anticipated to be slightly mobile based upon an approximated Koc of 3200. Benzophenone-2 has approximated pKa1 and also pKa2 worths of 7.1 and also 7.9, specifically, for carbon and also clay about their neutral counterparts. Based on an estimated Henry’s regulation constant of 3.6X10-16 atm-cu m/mole, volatilization of neutral types from wet dirt surfaces is not anticipated to be a considerable fate process. Likewise, it is not anticipated to volatilize from moist dirts, as the compound might exist in the form of anions, which do not volatilize. Based on its vapor stress, it is not anticipated to volatilize on dry dirt surface areas. Biodegradation data in dirt and also water are not offered. If launched right into water, 2 2 4 4 Tetrahydroxybenzophenone is expected to adsorb to suspended solids and also sediments based upon the approximated Koc. The volatilization of neutral varieties from water to the surface is not expected to be an important destiny process based on the approximated Henry’s law constant for this compound. Estimated pKa values recommend that 2 2 4 4 Tetrahydroxybenzophenone exists as an anion at pH 5 to 9, so surface area volatilization from water is not expected to be a crucial destiny process. A BCF of 1.9 shows low bioconcentration in marine microorganisms. Hydrolysis is not anticipated to be an essential ecological destiny procedure because the compound lacks useful groups that hydrolyze under ambient problems (pH 5 to 9). Work-related direct exposure to benzophenone-2 can happen via inhalation of dust (when made use of in powder kind) and also skin contact with the compound at offices where benzophenone-2 is generated or used. Use information as well as minimal security data recommend that the general populace might be revealed to benzophenone-2 via facial direct exposure to consumer items having 2 2 4 4 Tetrahydroxybenzophenone and also breathing of dust including benzophenone-2.

About Products:
If you need 2 2 4 4 Tetrahydroxybenzophenone as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of 2 2 4 4 Tetrahydroxybenzophenone, ZSpharmac will provide 2 2 4 4 Tetrahydroxybenzophenone raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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