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1,4-Butenediol CAS 110-64-5

Molecular Formula: C4H8O2

Formula Weight: 88.11

ZSpharmac: 1,4-Butenediol Raw Material Supplier

Product Name: 1,4-Butenediol
CAS No: 110-64-5
Purity: 99%

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Basic Info

Product Name:1,4-Butenediol
Other Names:2-Butene-1,4-diol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Sticky Yellow Oily
EINECS No.:203-787-0
Provide:1,4-Butenediol MSDS;
1,4-Butenediol COA

What is 1,4-Butenediol?

1,4-Butenediol, also known as 2-Butene-1,4-diol, is a clear liquid that is readily soluble in water and most organic solvents. It is a polar molecule with two hydroxyl functional groups that can form hydrogen bonds with water molecules. This compound has various applications in the pharmaceutical and cosmetic industries, as well as in the synthesis of pesticides and vitamin B6.

1,4-Butenediol Property

Melting point 4-10 °C(lit.)
Boiling point 235 °C(lit.)
density 1.07 g/mL at 25 °C(lit.)
refractive index n20/D 1.479
Fp >230 °F
solubility Chloroform (Soluble), DMSO (Slightly)
form Oil
color yellow


1,4-Butenediol Uses

  1. 1,4-Butenediol has various uses including as a plasticizer for alkyd resin, a cross-linking agent for synthetic resin, and a bactericide. It is also used in the production of 1,4-butanediol and other compounds.
  2. Additionally, 1,4-Butenediol serves as a pesticide and pharmaceutical intermediate. It is utilized in the synthesis of endosulfanol, an intermediate for the organochlorine pesticide endosulfan.
  3. Furthermore, 1,4-Butenediol is primarily employed as an intermediate in the manufacturing of pesticides, agricultural chemicals, and vitamin B6. It is also utilized in small quantities in polymer production.

1,4-Butenediol Applications

1,4-Butenediol is commonly used as an intermediate in organic synthesis and pharmaceutical chemistry, particularly in the production of fine chemicals and biologically active molecules. One significant application of 1,4-butenediol is in the synthesis of vitamin B6, also known as pyridoxine. Vitamin B6 is a crucial water-soluble vitamin that plays a vital role in human growth and development, as well as in the proper functioning of the nervous and immune systems.


In the synthesis process, sodium hydride (3.27 g, 60% in oil, 81.2 mmol) and tetrahydrofuran are added to a dry reaction flask, followed by the slow addition of 1,4-butenediol (3.0 g, 3.4 mmol). The reaction generates a significant amount of gas, so it is important to carefully manage the pressure changes. The resulting mixture is stirred at room temperature for several hours, after which a solution of methyl iodide (10.6 mL, 170 mmol) in tetrahydrofuran (60 mL) is added. The mixture is then stirred at 0°C for 10 minutes, followed by incubation at 25°C for 24 hours.

After the reaction, the mixture is slowly poured into 60 mL of brine and then extracted with diethyl ether (3 × 50 mL). The combined organic layers are dried over anhydrous magnesium sulfate, filtered to remove the desiccant, and the resulting filtrate is concentrated to obtain a colorless oil. The pure target product is obtained by distillation under reduced pressure.

1,4-Butenediol Production Methods

The process involves using catalytic hydrogenation to convert 1,4-butynediol into 1,4-butenediol. First, a 40% aqueous solution of butynediol is mixed with 50% Raney nickel, and ammonia inhibitor is added. Hydrogen gas is then introduced at a pressure of approximately 0.5kPa until the theoretical hydrogen absorption capacity is reached. The mixture is then filtered, and the filtrate is distilled under reduced pressure. The 110-114°C/8kPa fraction is collected to obtain 1,4-butenediol.

About Products:
If you need 1,4-Butenediol as a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced 1,4-Butenediol manufacturer and supplier, our company, ZSpharmac will provide 1,4-Butenediol raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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