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1,3-Propanediol CAS 504-63-2

Molecular Formula: C3H8O2

Formula Weight: 76.09

ZSpharmac: 1,3-Propanediol Supplier

Product Name: 1,3-Propanediol
CAS No: 504-63-2
Purity: 99%

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Basic Info

Product Name:1,3-Propanediol
Other Names:Propane-1,3-Diol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Oily Liquid
EINECS No.:207-997-3
Storage:Store Below +30°C.
Provide:1,3-Propanediol MSDS;
1,3-Propanediol COA

What is 1,3-Propanediol?

1,3-Propanediol is a new type of chemical raw material with great potential. It is widely used in the manufacture of polyester fibers, polyurethanes, hot melt adhesives, powder coatings, antifreeze agents, packaging materials and organic synthesis intermediates. Among them, the manufacture of high-performance polyester-polytrimethylene terephthalate (PTT) is the main application at present. 1,3-propanediol can be produced by chemical and biological routes, among which 1,3-propanediol is produced by biotechnology, which is characterized by its green chemistry, mild reaction conditions, easy operation, less by-products, less environmental pollution, The use of renewable resources and other characteristics has become one of the hot spots of biochemical research in the new century.

1,3-Propanediol Property

Melting point 

-27 °C (lit.)

Boiling point 

214 °C/760 mmHg (lit.)


1.053 g/mL at 25 °C (lit.)

vapor pressure 

0.8 mm Hg ( 20 °C)

refractive index 

n20/D 1.440(lit.)


>230 °F

storage temp. 

Store below +30°C.


H2O: soluble




Oily Liquid




4.5-7.0 (100g/l, H2O, 20℃)

explosive limit


Water Solubility 

100 g/L


1,3-Propanediol Applications

1,3-Propanediol (1,3-Propanediol, described as 1,3-PD) is an important solvent and also chemical resources, and also its existing primary use remains in the synthesis of polyester, polyether, polyurethane, and so on. Polyester PTT (polytrimethylene terephthalate) synthesized with 1,3-propanediol as well as terephthalic acid has a broad application prospect in the fields of synthetic fiber products, polyester films, design plastics as well as fabric as well as garments products. 1,3- Propylene glycol has actually been suggested for use in personal treatment formulations and cosmetics, yet is not known to be generally made use of in the food industry. 1,3-Propanediol is a polar compound that can be prepared from corn sugar. 1,3-propanediol can be made use of in food and beverage items to enhance the bitterness account compared to an otherwise similar food or drink product that does not consist of 1,3-propanediol. It has actually been remarkably and also unexpectedly found that including 1,3-propanediol in really small amounts in food and also drink items can subdue the bitter preference of certain active ingredients in food and beverage items. In one aspect, 1,3-propanediol is effective in lowering the bitterness connected with high strength sweeteners in food and beverage products. In a specifically chosen element, the high intensity sweetener consists of one or more steviol glycosides. In another facet, 1,3-propanediol works in decreasing the resentment related to salt substitutes such as potassium chloride in food as well as beverage items.

Generally, the 1,3-propanediol is consisted of in the food or drink product in such an amount that the 1,3-propanediol itself does not pass on flavor to the food or drink product and its addition in the item can not be viewed by taste. For instance, the inclusion of 1,3-propanediol is typically considered to be below the typical consumer sensory observable flavor threshold. To put it simply, there was no noticeable difference in preference in between the relative product without 1,3-propanediol and also the product consisting of 1,3-propanediol. The quantity of 1,3-propanediol can likewise be determined by dilution in water, if desired, to ensure that the 1,3-propanediol does not contribute taste to the food or drink.

Preparation of 1,3-Propanediol

At present, the production method of 1,3-propanediol is mostly a chemical synthesis approach, such as the ethylene oxide technique developed by the German Shell business, that is, ethylene oxide responds with carbon monoxide and also hydrogen under the activity of a catalyst to create 3-hydroxypropanal, which is separated 3-Hydroxypropanal is catalytically hydrogenated to 1,3-propanediol. The manufacturing price of the approach is lower, and also the hydroxyl web content of the acquired item is lower than that of the acrolein method. Nevertheless, the ethylene oxide path is technically difficult, specifically the preparation and also choice of its catalyst is fairly made complex. The chemical synthesis method has the drawbacks of huge tools financial investment, high technological problem, heavy metal driver, environmental pollution, and also tough separation and purification of items.

The study of microbial conversion of glycerol to 1,3-propanediol started in 1881, but it did not attract people’s interest till the 1990s. Compared with the chemical synthesis method, the microbial transformation method has a very wide application possibility due to its benefits of utilizing renewable resources, clean manufacturing, ecological friendliness, and sustainable growth. Currently, the microbial production technique of 1,3-propanediol can be separated right into 2 classes, one is to use genetically crafted bacteria to generate 1,3-propanediol (WO96/35796, WO98/21340, WO98/21339), and also the other is to use digestive tract bacteria to disproportionate glycerol It is 1,3-propanediol (USP5254,467, EP0373,230). The previous has the issues of reduced product focus and reduced conversion rate of glycerol. Although the latter has a high conversion price, its production as well as application are limited because of pathogenic microorganisms. Today, the production of 1,3-propanediol by biological approach is primarily produced by the fermentation of creating germs. The production of 1,3-propanediol by the metabolic rate of glycerol in microorganisms generally entails 2 steps of enzymatic responses: (1) Glycerol dehydratase (GDHt) transforms glycerol into intermediate items 3-hydroxypropionaldehyde (3-hydroxypropionaldehyde, 3-HPA); (2) 1,3-propanediol dehydrogenase (PDOR) catalyzes 3-HPA to create the final product 1 under the activity of NADH, 3-Propanediol. Research studies have revealed that throughout the fermentation procedure of 1,3-propanediol design bacteria, 3-HPA often tends to gather in big amounts, and also at the same time, different acidic substances are created, which seriously influences the catalytic task of PDOR, as well as the decrease of PDOR task will trigger 3-HPA is additional built up, forming a vicious circle, and also the development of the fermentation pressure is irreversibly stopped; additionally, because of the accumulation of 1,3-propanediol concentration in the fermentation broth, the catalytic activity of PDOR will certainly be prevented responses, affecting the final product 1,3- The accumulated focus of propylene glycol will seriously impact the yield of 1,3-propanediol. For that reason, PDOR, which is the crucial enzyme as well as rate-limiting enzyme for 1,3-propanediol production, plays a critical duty in the production of 1,3-propanediol.

Production Technology and Development Trend of 1,3-Propanediol

At present, there are three industrial 1,3-PDO production methods: acrolein hydration method, ethylene oxide hydroformylation method and biological fermentation method, among which acrolein hydration method was built by Degussa in 1996 with a capacity of 50,000 tons/ annual industrial device; the ethylene oxide hydroformylation method was built by Shell in 1999 with an industrial device of 72,000 tons/year; the biological fermentation method was built by DuPont in 2006 with an industrial device of 45,000 tons/year; The process includes formaldehyde-acetaldehyde condensation process, ethylene synthesis process via Prins reaction, glycerin chemical process and 3-hydroxypropionaldehyde (3-HPA) one-step synthesis process, etc. Because the biological fermentation method has the advantages of mild reaction conditions, simple operation, few by-products, and excellent selection. Good selectivity, low energy consumption, less investment in equipment, and environmental friendliness have made it a hot spot for development today.
2.1 Acrolein hydration method

The process developed by Degussa Company initially uses a special ion exchange resin catalyst, and adds a chelating functional group containing methyleneimine diacetic acid, reacts at 60 ° C, the conversion rate of acrolein is 82%, and 3-hydroxypropanal ( HPA) selectivity was 80%. Afterwards, 1,3-PDO is obtained by two-stage hydrogenation. When Raney nickel is used as the catalyst, the carbonyl content is reduced from 1000ppm to less than 100ppm. In 1998, Degussa transferred the technology to DuPont.
2.2 Ethylene oxide hydroformylation method

The process developed by Shell is carried out in two steps, that is, firstly, hydroformylation of ethylene oxide and synthesis gas to HPA, followed by hydrogenation to 1,3-PDO. The key to the Shell process is the use of cobalt carbonyl catalysts in the hydroformylation process, and the use of various ligands (such as diphosphine, trihydrogen phosphine, arsenic, etc.) base pyridine, etc.), based on ethylene oxide, the yield of 1,3-PDO can reach 85% to 90%, and the product purity can reach 99.6% (mass ratio).
2.3 Biological fermentation method

The method includes the selection of raw materials, fermentation process, removal of bacteria and protein, desalination and rectification.
Since the 1,3-PDO fermentation process includes microbial strains, proteins, nucleic acids, polysaccharides, inorganic salts, organic acid salts, glycerin, 2,3-butanediol, water, etc. in addition to the target product, it is a very complicated process. components, and 1,3-PDO has strong polarity and low concentration in the fermentation broth (about 50-110 g/L in one stage), so it is very difficult to separate and recover 1,3-PDO from the dilute solution, which is also a constraint on biological The key to 1,3-PDO production. In order to solve the many problems existing in the whole separation process, the purification process needs to be further optimized, especially to develop an economical and efficient separation method, while improving the yield and quality of 1,3-PDO, simplify the process route, reduce energy consumption, and recover A by-product with higher added value in the fermentation broth.

In addition to biological synthesis of 1,3-PDO, the chemical synthesis of 1,3-PDO from glycerol is also worthy of attention. For example, the research group of Tohoku University in Japan and Daicel Corporation have developed a 1,3-PFO process from biodiesel by-product glycerol. The process uses a powder-type Ir-ReOX/SiO2 catalyst, which is dispersed in the reaction solution, and the selectivity of 1,3-PDO reaches 60%. The research group also confirmed the reaction mechanism for the formation of 1,3-PDO via the 2,3-=hydroxypropanol intermediate. The research team also enabled the reaction to take place in a fixed-bed reactor by using an optimized spherical catalyst supported on silica gel. It has been continuously operated on a laboratory scale for more than 300 hours, showing that the catalyst can still maintain high activity and selectivity. Therefore, it can be considered that the scale-up test of the industrial route can be carried out, and the reaction by-product propanol can also be sold as a solvent. 3 Domestic and foreign market supply and demand and forecast

In recent years, foreign countries have seldom reported new 1,3-PDO production facilities. It is estimated that the current production capacity is 265,000 tons/year, the largest of which is Shell’s ethylene oxide hydroformylation unit in Geismar, Louisiana, USA, with a capacity of 136,000 tons/year; Degussa’s Weser, Germany There are two sets of acrolein hydration plants with a production capacity of 18,000 tons/year and 50,000 tons/year in the Wesseling area. DuPont has a 18,000 tons/year acrolein hydration plant in Germany and a set in Tennessee, USA. The bio-fermentation device of the company has a current production capacity of about 60,000 tons/year after a 30% capacity expansion in 2011. Shell has predicted that the demand for PTT, the main downstream product of 1,3-PDO, is expected to reach 1 million tons in the next few years, and the required 1,3-PDO will reach 360,000 tons. Obviously, the existing production capacity cannot meet the market demand.

At present, my country’s annual consumption of PTT has exceeded 30,000 tons, accounting for about 10% of the world’s total consumption. 90% of PTT consumption is directly used for spinning as fiber, and the remaining 10% is used for engineering plastics, of which about two-thirds of the fiber is used for clothing and one-third for carpets. In the next few years, the domestic PTT potential market demand will be 50,000-100,000 tons.

About Products:
If you need 1,3-Propanediol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced 1,3-Propanediol manufacturer and supplier, ZSpharmac will provide 1,3-Propanediol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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