Zhishang Chemical

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Zhishang Chemical

1,3-Butanediol CAS 107-88-0

Molecular Formula: C4H10O2

Formula Weight: 90.12

ZSpharmac: 1,3-Butanediol Supplement

Product Name: 1,3-Butanediol
CAS No: 107-88-0
Purity: 99%

Basic Info

Product Name:1,3-Butanediol
Other Names:(±)-1,3-Butanediol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Yellow Liquid
EINECS No.:203-529-7
Storage:Store Below +30°C.
Provide:1,3-Butanediol MSDS;
1,3-Butanediol COA

What is 1,3-Butanediol?

1,3-Butanediol is mainly used as a moisturizing agent in cosmetics, and has a good antibacterial effect, and can be used in the production of various lotions, ointments and toothpastes. 1,3-Butanediol is also the raw material of polyester resin and alkyd resin. Its various monocarboxylic acid monoesters are excellent plasticizers for PVC resins and plastics; The body can be made of unsaturated polyester resin. Since 1,3-butanediol has an antibacterial effect, it is also used as an antibacterial agent for dairy and meat products. The toxicity of 1,3-butanediol to advanced animals is very low, which is comparable to the toxicity of glycerol, lower than that of 1,4-butanediol, and the median lethal dose to rats is 22.8~29.5g·kg The median lethal dose was 23.4g·kg-1.

1,3-Butanediol Properties:

Melting point -54 °C
Boiling point 203-204 °C(lit.)
density 1.005 g/mL at 25 °C(lit.)
vapor density 3.1 (20 °C, vs air)
vapor pressure 0.06 mm Hg ( 20 °C)
refractive index n20/D 1.44(lit.)
Fp 250 °F
storage temp. Store below +30°C.
solubility >500g/lMiscible
form Liquid
color Clear colorless to yellow, may discolor to brown on storage
Specific Gravity1.004 – 1.007
PH6.1 (500g/l, H2O, 20℃)
PH Range6 – 7 at 20 °C
explosive limit1.9-12.6%(V)
Water Solubility SOLUBLE


1,3-Butanediol Uses

  1. 1,3-Butanediol is utilized as service provider solvent (primarily utilized in curries); flavors.
  2. 1,3-Butanediol is made use of as an emollient and also is additionally used in organic synthesis.
  3. 1,3-Butanediol has the features of diol sensitivity, odorless, reduced toxicity as well as great water solubility, as well as can be utilized in the complying with major facets:
    ( 1) Unsaturated polyester prepared by mixing 1,3-butanediol or ethylene glycol as resources for polyester material and also alkyd resin has great water resistance, versatility and influence resistance.
    ( 2) The raw material utilized as plasticizer is a polyester plasticizer made from 1,3-butanediol and also dibasic acid (adipic acid), which has reduced volatility, movement resistance, soapy water resistance, as well as Solvent and oil resistance.
    ( 3) Made use of as raw material of polyurethane finishing As the raw product of saturated polyester for polyurethane finishing, the obtained item can get great water resistance in unpainted paint, and the impact is better than that of other diols.
    ( 4) Used as a moistening agent as well as softener, 1,3-butanediol has outstanding moisturizing buildings and also low poisoning. After being made into an ester, it can be used as a moisturizing as well as softening representative for cigarettes, celluloid, vinylon films, paper as well as fibers, etc representative.
    ( 5) Solvents utilized as fine chemicals can be made use of in formulations of lotions, creams, lotions and toothpastes.

Preparation of 1,3-Butanediol

Propylene and formaldehyde react as follows in the presence of an acidic catalyst:

Reactions (5) and (6) belong to typical Prins addition reactions. The Prince reaction of propylene with formaldehyde needs to be carried out in polar solvents and acidic catalysts. Commonly used solvents are water, ethanol and acetic acid, etc. Studies have shown that acetic acid is the most ideal solvent. The catalyst can be H2SO4, BF3, HClO4, etc., among which HClO4 has the best catalytic effect. However, due to the strong corrosiveness of H2SO4 and HClO4, H+ type cation exchange resin is used as the catalyst in actual production.

The composition of the Prince reaction product of propylene and formaldehyde is more complicated. The main product is 1,3-butanediol, and the by-products are 4-methyl-1,3-dioxane, formal, etc. When acetic acid is used as a solvent, 1,3-butanediol acetates are by-products. The 4-methyl-1,3-dioxane hydrolysis method can improve the yield of 1,3-butanediol, that is, the reverse reaction of reaction (6) is carried out.

The condensation hydrolysis of propylene and formaldehyde was industrialized in the 1970s. The specific process adopts a two-step method, replacing the H2SO4 catalyst with a KU-2(H+) cation exchange resin. The first step: 4-methyl-1,3-dioxane prepared by condensation of propylene and formaldehyde solution; the second step: 4-methyl-1,3-dioxane in the presence of methanol Hydrolysis, the function of methanol is to condense with the hydrolyzed formaldehyde into easily separated methylal.

The process flow is briefly described as follows: After preheating the industrial grade formaldehyde aqueous solution and the industrial propylene-propane mixture respectively, they are fed through the bottom of the vertical tubular reactor to carry out the condensation reaction. The reactor is equipped with KU-2 (H+) type Cation exchange resin reaction conditions: 100~110℃, 30×105~40×105Pa. The condensation reaction product is decompressed to 1.0×105Pa and then sent to the 1# tower to separate propane and unreacted propylene, and the recovered propylene can be recycled after purification. The reaction product of removing propylene propane is composed of: 4-methyl-1,3-dioxane, water, methylal and a small amount of high boilers; the reaction product of removing propylene propane is in the 2# tower. head, remove methanol and methylal; separate propane and unreacted propylene, the recovered propylene can be recycled after purification; in the 3# tower, remove methanol and methylal; separate propane and unreacted propylene, The recovered propylene can be recycled after purification treatment; 4-methyl-1,3-dioxane and water are distilled out in the form of azeotrope, and the azeotrope is 88°C. The organic phase separated from the azeotrope is mixed with methanol in a ratio of 1:3 through a mixer, and then passed into a vertical hydrolyzer for hydrolysis. The hydrolyzer is also equipped with KU-2 (H+) type cations exchange resin. Hydrolysis conditions: 80~90℃, feed rate 25h-1. The conversion rate of 4-methyl-13-dioxane is higher than 85%. The hydrolyzed product is rectified in the 4# rectification tower to obtain high-purity 1,3-butanediol. 4# rectification tower operating conditions: 104℃, 1.33kPa

The Effect of 1,3-Butanediol on The Skin

1,3-Butanediol is used in shampoos and conditioners for damaged hair and in low humidity areas.

Emollients have the effect of softening and softening the skin. Common polyol moisturizers have the function of emollients; on the contrary, emollients may not have the effect of moisturizing. Oil-in-water emulsions/creams based on mineral oil [(contains

5% of 1,3-butanediol, glycerin or propylene glycol) and (10% white wax oil)] let the testers evaluate the skin feel and efficacy after wiping. The test results show that 1,3-butanediol has the following advantages over glycerol and propylene glycol:

1,3-Butanediol is less greasy than glycerin and propylene glycol.

It is less sticky than glycerin.

1,3-Butanediol is more easily absorbed by the skin than glycerin.

1,3-Butanediol is less film-forming than glycerol and propylene glycol.

1,3-Butanediol Provides a smoother skin feel than glycerin.

The sensitization and potential irritation of cosmetic raw materials to the skin is an important criterion for formulators to choose. Research to date has shown that 1,3-butanediol is significantly less irritating and sensitizing to the skin than propylene glycol.

1,3-Butanediol is more oil soluble than glycerol and propylene glycol, but still miscible with water. 1,3-Butanediol is used to dissolve the active ingredient in ointments, creams and lotions. 1,3-Butanediol has good solvent properties, so it can be added to products such as face wash, makeup remover, and hair dye. In fragrance applications, it is used as a flavor solubilizer and fixative.

All in all, 1,3-butanediol is far superior to propylene glycol (PG) in skin irritation and sensitization, better than propylene glycol and glycerin, and has better moisturizing properties than propylene glycol and glycerin. Can improve the skin, and can improve the skin’s feel. Since butanediol acts as a humectant, emollient, solvent, and fragrance fixative, it can be used in the following types of personal care products:

moisturizing cream, moisturizing milk, moisturizing cream;

Essence, lotion, aftershave, makeup remover;

Makeup products such as mascara, eyeliner, and barrier cream;

Shampoo and conditioner (especially for damaged and dry hair);

Sunscreen products, anti-aging and anti-wrinkle care products.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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