The disadvantage of the synthesis method of 1,2-octanediol is that the manufacturing cost is reasonably high. The objective of the creation is to create a sort of artificial approach of 1,2-octanediol. What the here and now innovation intends to solve is the trouble of reasonably high cost in the existing synthesis of 1,2-octanediol.
The synthesis steps of the here and now innovation are as follows: in the reaction pot geared up with stirring, thermometer and also head container, add one of formic acid, acetic acid, acetic acid, antarctic acetic acid and hydrogen peroxide, begin stirring, after that include 1-octene, add After conclusion, maintain the reaction mix service for 5 mins to 600 minutes, then distill off the residual acid and also water under lowered stress, then add salt hydroxide remedy under stirring until the pH value of the mix service gets to the specific demands, and after that include ester or natural solvent to remove, The obtained extract is washed with sodium chloride, the washed essence is dried out with anhydrous magnesium sulfate, and afterwards distilled under reduced stress, and also the distilled portion is the item 1,2-octanediol.
The focus of sodium chloride used for washing is 20-40%, and also the cleaning is executed one to three times, and also fractions are accumulated under the problem of 120-140 ° C/1300 -1400 Pa. The esters or organic solvents used are all classes in chemicals. The pH worth of the combination service remains in all series of alkali. The response temperature in the reactor is managed at 20-90 ° C.
Compared to the existing artificial method, the present development has the advantage of low production expense.
The creation appropriates to be made use of as an intermediate for synthetic essence, lubing oil additive, plasticizer, adhesive, cosmetics, state-of-the-art ink and so forth.
36-38 °C (lit.)
131-132 °C/10 mmHg (lit.)
>1 (vs air)
0.28Pa at 25℃
Sealed in dry,Room Temperature
3 g/L (20°C)
Low Melting Solid
Colorless to white
3 g/L (20 ºC)
Application of 1,2-Octanediol
CN200780041024.X has really reported a kind of eyelid scrubbing up structure, and it consists of polyhexamethylene biguanide (PHMB), 1,2-hexanediol, 1,2-octanediol, and also exists with efficient amount to ensure that the make-up The pH degree is managed in between 5.5 and 7.5 for a pH maintained surfactant remedy. The composition might furthermore consist of humectants as well as likewise foam stabilizers. The framework can be used as an eyelid scrub in combination with a material pad pre-moistened with the framework and packaged for usage. The cosmetics can be associated with an eyelid scrub and also can be massaged right into a soap. The make-up can be prepared by preparing a changed Ringer’s remedy as well as including 1,2-hexanediol, 1,2-octanediol along with an effective amount of one or more pH sustaining active agents. The mix sought that warmed and allowed to cool before consisting of the polyhexamethylene biguanide.
Preparation of 1,2-Octanediol
Report one Include formic acid and also hydrogen peroxide to a response pot geared up with mixing, a thermostat and also a head container, begin stirring, and after that add 1-octene. After the addition, the response mixture remedy is kept for 100 minutes, and then the formic acid as well as hydrogen peroxide are evaporated under decreased pressure. water, and then include salt hydroxide service under mixing until the pH worth of the combination solution is alkaline, then add esters for extraction, and also the resulting extract is washed twice with 30% sodium chloride, and also the washed remove is added without Distillate under reduced stress after dehydration with magnesium sulfate water, accumulate fractions under the condition of 131 ° C/1330Pa, as well as the obtained fractions are the product 1,2-octanediol. The response temperature level in the reactor is regulated at 20-90 ° C.
1. Synthesis In a four-neck flask, set up an electrical stirrer, a condenser, a thermostat, an exterior cold water bath, and also a going down channel. Include metered amounts of formic acid, hydrogen peroxide, and driver in turn in the flask, and also stir intensely to completely blend. Under external air conditioning, go down the metered amount of 1-octene, manage the temperature in the bottle to respond at 35 ° C-40 ° C, after the dropwise enhancement, keep the response at 40 ° C-45 ° C for 3-4h, and then mix at area temperature level After reacting for 1-2h, a clear as well as clear combined remedy can be gotten. The clear and also transparent blended solution was distilled off of water and also excess formic acid under high vacuum till only oil remained.
2. Neutralization and extraction In a four-neck flask, configure an electric stirrer, a thermometer, a cold water bath, a condenser, and a going down funnel. Place the above oil right into the flask, switch on the stirrer, manage the temperature in the bottle at 40 ° C-45 ° C, add 30 %NaOH remedy dropwise for neutralization, and also include sufficient NaOH service to raise the pH value of the remedy to 12 -13. When the pH value is secure, take a sample for evaluation, and also counteract the gotten blended solution with 30% HCI at 20 ° C to make the pH value of the blended remedy 7, as well as the neutralization time has to do with 3 hours. Add strong NaCl to the blended service to make the water phase right into a saturated saline blended option. After that add a suitable quantity of ethyl acetate for extraction, and also the essence is filled with
Cleaned with salt water, lastly dried out over anhydrous Na2SO4, and also vacuum filtered.
3. Purification Concentrate the filtrate under lowered stress, boil down off ethyl acetate until just the oil continues to be; then boil down the oil under reduced pressure at 1.33 * 103Pa to boil down the product, which is an anemic, transparent liquid with a pungent odor. Examined by gas chromatograph FID-6890 area normalization approach, the material is above 99%.
About Products: If you need 1,2-Octanediol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price. As an experienced 1,2-Octanediol manufacturer and supplier, ZSpharmac will provide 1,2-Octanediol raw materials to customers all over the world for a long time. Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.
Company Profile and Corporate Culture
ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .
The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .
The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.
OUR MISSION Help China Chemicals to benefit the happiness of human life OUR VISSION Become the most trusted chemical supplier in the world OUR BUSINESS PHILOSOPHY Striver – oriented, enrich employees, customer first, deep service, seek development OUR VALUES Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight
The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.
“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.
Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.
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We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
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You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
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Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
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Different quantity has different discount.
1. ≤50kg, Express delivery recommended, usually called as DDU service;
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