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1-Naphthol CAS 90-15-3

Molecular Formula: C10H8O

Formula Weight: 144.17

ZSpharmac: 1-Naphthol Supplier Manufacturers

Product Name: 1-Naphthol
CAS No: 90-15-3
Purity: 99%

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Basic Info

Product Name:1-Naphthol
Other Names:1-Naphthalenol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Crystalline Flakes
EINECS No.:201-969-4
Storage:Store Below +30°C.
Provide:1-Naphthol MSDS;
1-Naphthol COA

What is 1-Naphthol?

Naphthol is a material in which one hydrogen atom on the naphthalene ring is modified by a hydroxyl group. There are 2 isomers of α- together with similarly β-naphthol, furthermore called 1-naphthol and likewise in addition 2-naphthol. The molecular therapies are all C10H7OH, together with the structural formulas exist in the number. All white crystals. The α-isomer is needle crystal, with a melting point of 96 ° C together with a liked one density of 1.099 (99/4 ° C). It can be volatilized with water vapor or sublimated. The β-isomer is an orthorhombic crystal with a melting point of 123-124 ° C along with a density of 1.28 g/cm3 (20 ° C). Both are insoluble in water, nevertheless swiftly soluble in natural solvents such as ethanol, benzene, together with in a similar way chloroform.Soluble in salt hydroxide treatment to create the matching salt naphthol. A color feedback will absolutely take place when finding ferric chloride fluid option, the α-isomer is purple, along with additionally the β-isomer is environment-friendly. Naphthalene can be sulfonated at various temperature level levels initially, such as reacting with focused sulfuric acid at around 60 ° C to obtain α-naphthalenesulfonic acid, in addition to reacting at 160 ° C to get β-naphthalenesulfonic acid; afterwards eutectic them with salt hydroxide respectively Generate naphthol sodium salt, which is eventually managed acidification. They are flammable as well as additionally worsening, together with breathing of a substantial quantity of naphthol dust or vapor can create poisoning, with signs and also indications such as convulsions, vomitting, in addition to similarly coma.

1-Naphthol Property

Melting point 94-96 °C(lit.)
Boiling point 278-280 °C(lit.)
density 1.224
vapor density 4.5 (120 °C, vs air)
vapor pressure 1 mm Hg ( 94 °C)
refractive index 1.6224
Fp 125 °C
storage temp. Store below +30°C.
solubility Soluble in benzene, chloroform, ether and ethanol.
form Crystalline Flakes
pka9.34(at 25℃)
color white to off-white
OdorSlight phenolic odor
explosive limit5%
Water Solubility 436.7mg/L(25 ºC)


Application of 1-Naphthol

As an intermediate, 1-Naphthol is widely used in the synthesis and production of dyes, flavors, oils, medicines and also pesticides. Its application instances are as follows:

1. Synthesis of 1,4-naphthoquinone., 4-Naphthoquinone is a crucial chemical intermediate, mostly utilized as a resources for the synthesis of great chemical products such as dyes, chemicals, medicines, fungicides, rubber, photosensitive products, organic pigments, and heat-sensitive recording materials. Polymerization regulator for rubber and materials. There are lots of methods to synthesize 1,4-naphthoquinone, mainly using 1-Naphthol, α-naphthylamine, 1,4-aminonaphthol, naphthalene, etc as resources through oxidation. The oxidant can be chromic anhydride, sodium dichromate, potassium dichromate, air, and so on. Most of the domestic use of naphthalene catalytic oxidation in the presence of barium pentoxide. This response effectiveness is reduced, as well as side response is several. Research study has offered a synthesis method of 1,4-naphthoquinone, which does not use any kind of stimulant, is low in cost, is eco-friendly, straightforward in operation and also high in yield. The particular steps are as adheres to: mix H2O2 and also acetic anhydride in a molar ratio of 1-4:1 and also fully respond to get peracetic acid; add a remedy of α-naphthol to the gotten peracetic acid, and heat Under full response, obtain reaction fluid, contain 1,4-naphthoquinone in the described response fluid, in which the mol proportion of the α-naphthol in the α-naphthol solution and also the acetic anhydride defined in step A is 1:1 -15; In this method, H2O2 as well as acetic anhydride are directly responded to manufacture peracetic acid under an acid-free stimulant, which reduces the reaction cost and also does not contaminate the setting; in this method, peracetic acid does not need to be distilled for standby, and α-naphthol is straight included dropwise to the activator The solution boosts the utilization price of peracetic acid, simplifies the reaction operation, as well as lowers the danger of surge of peracetic acid at 110 ° C; the here and now development does not utilize any type of stimulant, is low in expense, pleasant to the atmosphere, simple in operation, as well as simple to generate. High rate.

2. Prep work of α-methoxynaphthalene. The certain actions are as follows: α-naphthol is added dropwise with dimethyl sulfate under alkaline conditions to react, after that warmed to 60 ° C ~ 80 ° C, maintained for 3 ~ 6 hours, as well as acquired by unfavorable stress purification. The alkaline option used is among sodium hydroxide and potassium hydroxide, its focus is between 10% and 30%, as well as the molar proportion of reaction feed is 1-Naphthol: dimethyl sulfate: sodium hydroxide (or potassium hydroxide) = 1: 1.8 ~ 2.3: Between 2 as well as 2.5, the alkaline solution is added in stages during the response, which has the advantages of reduced production cost as well as high item return (≥ 95%).

3. Preparation of Naftopidil. Naftopidil is a discerning α1 receptor antagonist, which can inhibit the increase in high blood pressure triggered by α1 receptors, as well as additionally has calcium ion enmity. Pharmacodynamic tests have revealed that this item has antihypertensive impacts on various animal versions of hypertension, long duration of antihypertensive, does not create reflex tachycardia during antihypertensive, no noticeable first-dose impact as well as medication resistance after repeated oral management. The outcomes of heart hemodynamic examinations show that this product can decrease the total peripheral resistance as well as expand outer blood vessels in anesthetized open-chest canines without significant impact on heart result. It can additionally ease the tension of sympathetic nerves dispersed in the prostate as well as urethra, reduce the interior stress of the urethra, and also boost dysuria triggered by benign prostatic hypertrophy, specifically ideal for clients with hypertension, hyperlipidemia, diabetes, and benign prostatic hyperplasia. The details preparation technique comprises heating 1-(2-methoxyphenyl)-4-(oxiranylmethyl)-piperazine, 1-Naphthol and also a not natural base to the boiling point of the solvent in an organic solvent, mixing at reflux The reaction is performed under the problems, and after the conclusion of the reaction, naftopidil is gotten via post-processing. The prep work method is novel, the item yield is high, the item is high in purity, and also the operation is straightforward, and it is suitable for commercial production to create superb antihypertensive medicines.

4. Detect the sugar content in the water. Extreme sugar content in water will certainly cause sugar scale in the central heating boiler. The reason why sugar range is called the source of all evils is that it is an inadequate conductor of heat. Sugar range is formed on the evaporation surface of the central heating boiler, which decreases the thermal conductivity as well as reduces the temperature of the central heating boiler. The output of the central heating boiler minimizes the dissipation of water in the central heating boiler. In order to increase the temperature level of the heater as well as enhance the output of the boiler, fuel intake need to be increased, leading to energy waste. Therefore, it is needed to swiftly evaluate the industrial discharge water body at any time, provide the data of the real-time sugar content in the water, carry out the on-line surveillance of the sugar material in the industrial discharge water body of the sugar manufacturing facility, and take matching procedures in time to make sure the regular as well as risk-free operation of the business central heating boiler. The details detection method is as follows: under the condition of concentrated sulfuric acid, 1-Naphthol is made use of as a chromogen to respond sugar with focused sulfuric acid to create furfural and also its derivatives, and further condense with α-naphthol to create a purple complicated. The photoelectric colorimeter steps as well as records the modification value of the transmitted light intensity after the purple-red condensate reacted in the fluid flow absorbs the 595nm wavelength light, gets a feedback contour with equivalent peak height and also optimal size, and contrasts the peak height of the contour with the recognized sugar concentration The peak height of the light absorption contour of the conventional sample water is compared, and the sugar material worth in the water example is obtained via contrast calculation. The creation can detect low-content sugar web content in water or remedy online, the procedure is straightforward and also quickly, and the detection data is accurate and also reliable. The water example utilized for one discovery injection is just 50 μl ~ 1ml, the amount of reagent taken in at once is extremely tiny, and the operating cost is low. safe as well as safe.

1-Naphthol Production Method

α-naphthalenesulfonic acid antacids blend technique
Naphthalene is utilized as resources, sulfonated with concentrated sulfuric acid at low temperature (listed below 40 ° C )to acquire α-naphthalenesulfonic acid, and after that 1-naphthol can be prepared by alkali combination at 310-320 ° C
. The overall yield of this approach has to do with 40%, the by-product 2-naphthol is more, and also the consumption of acid and antacid is huge. Usage chlorosulfonic acid rather than focused sulfuric acid for sulfonation, use o-nitroethylbenzene as a solvent, and then undertake alkali fusion to get 1-naphthol. The yield is about 72%, and also the quantity of 2-naphthol is lowered. Solvent intake.

α-naphthylamine hydrolysis approach
Making use of α-naphthylamine as raw material, it is hydrolyzed under pressure in 15% -20% sulfuric acid.
The reaction temperature level is 200 ° C, as well as the pressure is 1.2-1.5 MPa. The hydrolyzate is divided, the ammonium bisulfate produced is recuperated, and also 1-naphthol with a content of 96% to 98% is obtained with neutralization as well as distillation, and the return is nearly 90%. The process of this technique is reasonably straightforward, however the toxicity of α-naphthylamine is high, and also the problems of equipment deterioration security and wastewater treatment are significant.
If α-chloronaphthalene is used for hydrolysis, the temperature level as well as pressure conditions are higher, the reaction pressure has to do with 5MPa, as well as the response temperature has to do with 270 ° C, and a copper stimulant is called for.

Tetrahydronaphthalene method
Naphthalene is used as raw material to acquire tetrahydronaphthalene via hydrogenation, and then oxidized and also dehydrogenated to acquire 1-naphthol.
The hydrogenation of naphthalene to tetrahydronaphthalene makes use of industrial hydrogenation molybdate stimulant and also “adiabatic” reaction gadget, the stress is about 3MPa, the ordinary reaction temperature is 300 ° C, the feeding area speed is 0.8h-1, and also the hydrogen/naphthalene ratio is 2500-6400 (volume proportion), the conversion price of naphthalene in one pass can get to 85%, the choice of tetralin can reach more than 92%, the purity of tetralin after correction can reach greater than 98%, and the overall return of hydrogenation and also refining is 85.5%.
Tetralin is oxidized to generate tetralone, utilizing multi-section bubble column continual liquid stage oxidation, utilizing air as oxidant, running under regular stress, using chromium acetate as well as 2-methyl-5-ethylpyridine composite catalyst, the response temperature level is 130 ° C, the molar ratio of tetralin to oxygen is 1:0.6, and also the residence time is 60-70min. The single-pass conversion price of tetralone is more than 20%, the selectivity of generating tetralone is about 90%, as well as the space-time return of the reactor is greater than 100g tetralone (L · h). The product can acquire 98% tetralone via vacuum fractionation, the unconverted tetralone can be reused as well as recycled, as well as the complete return of oxidation and also product refining is 85.5% (determined by tetralone).
The dehydrogenation of tetralone to methyl naphthol is a gas-phase catalytic reaction at air pressure, using a platinum/coarse-pore silica gel (or platinum/activated alumina) driver as well as a fixed-bed activator. The preliminary reaction temperature is 350 ° C, and also the feeding space rate is 0.8h-1, the molar proportion of tetralone raw material and hydrogen is 1: 3. The typical conversion rate of tetralone dehydrogenation response has to do with 85%, and also the average yield reaches greater than 93%. matter). The complete return of naphthalene via 3 steps of hydrogenation, oxidation and dehydrogenation (including item refining) is 65.4%. The major basic material usage quota for producing per lots of naphthalene is 1.39 t of naphthalene as well as 600m3 of hydrogen. This method is the path taken on by large-scale manufacturing in international countries currently, as well as it has actually been continually enhanced in recent times. It has reasonable process, reasonably innovative technology, easy-to-obtain raw materials (except naphthalene, generally hydrogen and air), high item high quality (basically does not include β-isomers), reduced manufacturing price, much less 3 wastes, and also the entire procedure is convenient. Continuous and automatic control, ideal for large manufacturing and also various other benefits, is an appealing procedure route.

About Products:
If you need 1-Naphthol this cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company as an experienced 1-Naphthol manufacturer and supplier,ZSpharmac will provide 1-Naphthol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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