As an intermediate, 1-Naphthol is widely used in the synthesis and production of dyes, flavors, oils, medicines and also pesticides. Its application instances are as follows:
1. Synthesis of 1,4-naphthoquinone., 4-Naphthoquinone is a crucial chemical intermediate, mostly utilized as a resources for the synthesis of great chemical products such as dyes, chemicals, medicines, fungicides, rubber, photosensitive products, organic pigments, and heat-sensitive recording materials. Polymerization regulator for rubber and materials. There are lots of methods to synthesize 1,4-naphthoquinone, mainly using 1-Naphthol, α-naphthylamine, 1,4-aminonaphthol, naphthalene, etc as resources through oxidation. The oxidant can be chromic anhydride, sodium dichromate, potassium dichromate, air, and so on. Most of the domestic use of naphthalene catalytic oxidation in the presence of barium pentoxide. This response effectiveness is reduced, as well as side response is several. Research study has offered a synthesis method of 1,4-naphthoquinone, which does not use any kind of stimulant, is low in cost, is eco-friendly, straightforward in operation and also high in yield. The particular steps are as adheres to: mix H2O2 and also acetic anhydride in a molar ratio of 1-4:1 and also fully respond to get peracetic acid; add a remedy of α-naphthol to the gotten peracetic acid, and heat Under full response, obtain reaction fluid, contain 1,4-naphthoquinone in the described response fluid, in which the mol proportion of the α-naphthol in the α-naphthol solution and also the acetic anhydride defined in step A is 1:1 -15; In this method, H2O2 as well as acetic anhydride are directly responded to manufacture peracetic acid under an acid-free stimulant, which reduces the reaction cost and also does not contaminate the setting; in this method, peracetic acid does not need to be distilled for standby, and α-naphthol is straight included dropwise to the activator The solution boosts the utilization price of peracetic acid, simplifies the reaction operation, as well as lowers the danger of surge of peracetic acid at 110 ° C; the here and now development does not utilize any type of stimulant, is low in expense, pleasant to the atmosphere, simple in operation, as well as simple to generate. High rate.
2. Prep work of α-methoxynaphthalene. The certain actions are as follows: α-naphthol is added dropwise with dimethyl sulfate under alkaline conditions to react, after that warmed to 60 ° C ~ 80 ° C, maintained for 3 ~ 6 hours, as well as acquired by unfavorable stress purification. The alkaline option used is among sodium hydroxide and potassium hydroxide, its focus is between 10% and 30%, as well as the molar proportion of reaction feed is 1-Naphthol: dimethyl sulfate: sodium hydroxide (or potassium hydroxide) = 1: 1.8 ~ 2.3: Between 2 as well as 2.5, the alkaline solution is added in stages during the response, which has the advantages of reduced production cost as well as high item return (≥ 95%).
3. Preparation of Naftopidil. Naftopidil is a discerning α1 receptor antagonist, which can inhibit the increase in high blood pressure triggered by α1 receptors, as well as additionally has calcium ion enmity. Pharmacodynamic tests have revealed that this item has antihypertensive impacts on various animal versions of hypertension, long duration of antihypertensive, does not create reflex tachycardia during antihypertensive, no noticeable first-dose impact as well as medication resistance after repeated oral management. The outcomes of heart hemodynamic examinations show that this product can decrease the total peripheral resistance as well as expand outer blood vessels in anesthetized open-chest canines without significant impact on heart result. It can additionally ease the tension of sympathetic nerves dispersed in the prostate as well as urethra, reduce the interior stress of the urethra, and also boost dysuria triggered by benign prostatic hypertrophy, specifically ideal for clients with hypertension, hyperlipidemia, diabetes, and benign prostatic hyperplasia. The details preparation technique comprises heating 1-(2-methoxyphenyl)-4-(oxiranylmethyl)-piperazine, 1-Naphthol and also a not natural base to the boiling point of the solvent in an organic solvent, mixing at reflux The reaction is performed under the problems, and after the conclusion of the reaction, naftopidil is gotten via post-processing. The prep work method is novel, the item yield is high, the item is high in purity, and also the operation is straightforward, and it is suitable for commercial production to create superb antihypertensive medicines.
4. Detect the sugar content in the water. Extreme sugar content in water will certainly cause sugar scale in the central heating boiler. The reason why sugar range is called the source of all evils is that it is an inadequate conductor of heat. Sugar range is formed on the evaporation surface of the central heating boiler, which decreases the thermal conductivity as well as reduces the temperature of the central heating boiler. The output of the central heating boiler minimizes the dissipation of water in the central heating boiler. In order to increase the temperature level of the heater as well as enhance the output of the boiler, fuel intake need to be increased, leading to energy waste. Therefore, it is needed to swiftly evaluate the industrial discharge water body at any time, provide the data of the real-time sugar content in the water, carry out the on-line surveillance of the sugar material in the industrial discharge water body of the sugar manufacturing facility, and take matching procedures in time to make sure the regular as well as risk-free operation of the business central heating boiler. The details detection method is as follows: under the condition of concentrated sulfuric acid, 1-Naphthol is made use of as a chromogen to respond sugar with focused sulfuric acid to create furfural and also its derivatives, and further condense with α-naphthol to create a purple complicated. The photoelectric colorimeter steps as well as records the modification value of the transmitted light intensity after the purple-red condensate reacted in the fluid flow absorbs the 595nm wavelength light, gets a feedback contour with equivalent peak height and also optimal size, and contrasts the peak height of the contour with the recognized sugar concentration The peak height of the light absorption contour of the conventional sample water is compared, and the sugar material worth in the water example is obtained via contrast calculation. The creation can detect low-content sugar web content in water or remedy online, the procedure is straightforward and also quickly, and the detection data is accurate and also reliable. The water example utilized for one discovery injection is just 50 μl ~ 1ml, the amount of reagent taken in at once is extremely tiny, and the operating cost is low. safe as well as safe.