N-methylimidazole is a vital resources for manufacturing pharmaceutical intermediates, made use of for the preparation of losartan, nitazofenone, 1-methylimidazole-5-formyl chloride hydrochloride as well as naphthimidazole hydrochloride, etc; in the field of pesticides, is commonly made use of in the synthesis of fungicides as well as plant growth promoters, for instance: N-methylimidazole is used as a cationic moms and dad to undergo quaternization response to synthesize ionic fluids of imidazoles; on top of that, N-methylimidazole is likewise used in epoxy resins as well as other material treating representatives, adhesives, etc; N-methylimidazole also has a terrific application in the field of spreading and glass fiber enhanced plastics.
Gadobutrol is a gadolinium-containing contrast agent made use of in nuclear spin tomography and has been used in Approved in the indicator “Comparison Zoom in Magnetic Vibration Tomography of the Cranial and also Spine”. By using weak bases such as lithium hydroxide or N-methylimidazole, this technique has the advantage of high throughput without the requirement for seclusion and also intermediate purification of intermediates. In the process, lithium salts can advantageously be recuperated and after that fed back right into the production cycle once more.
Compared to previous art approaches, waste generation is a lot more beneficial since all actions are executed in one “pot”, consequently eliminating mom liquor work-up, cleansing of filter systems, etc. By accurately identifying the ligand material before gadolinium complexation, gadolinium in wastewater can be effectively prevented because the amount of gadolinium can be readjusted as though all metals are complexed by butanol ligands. The technique can be managed with agitators and filter tools.Intermediate clean-up is performed with water only, no drying is required, and subsequent preparations can be carried out directly. This ensures optimal equipment usage and allows semi-continuous operation.
In addition, it can also be used to prepare ionic liquid corrosion inhibitors for oilfield water. Using N-methylimidazole as the starting material, the imidazole-type ionic liquid synthesized by a two-step method is used as the main agent for sustained release, and several other compounds are added as auxiliary retarders. Synthetic oilfield water injection compound corrosion inhibitor with release agent. This method can be carried out in sequence as follows:
(1) At a certain temperature, the N-methylimidazole and bromo-n-butane or benzyl chloride are mixed and reacted under stirring, and after the reaction for several hours, the unreacted substances are washed and removed to obtain the halide of N-methylimidazole.
(2) mixing the product obtained in step (1) with the selected compound, adding a solvent, stirring and reacting at a certain temperature for a period of time, the reaction solution is extracted, washed, and treated by removing the solvent to obtain each target product.
(3) Compounding the product obtained in step (2) with urotropine, OP-10, potassium iodide and thiourea in a certain proportion to obtain a corrosion inhibitor with extremely high corrosion inhibition efficiency. The raw materials required by the invention are simple and easy to obtain, the operation process is simple and safe, the reaction time is short, the cost is low, the yield is high, the corrosion inhibition performance is strong, and the invention is suitable for industrial scale production and has strong practicability.