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1-Methylimidazole CAS 616-47-7

Molecular Formula: C4H6N2

Formula Weight: 82.1

ZSpharmac: 1-Methylimidazole Supplement

Product Name: 1-Methylimidazole
CAS No: 616-47-7
Purity: 99%

Basic Info

Product Name:1-Methylimidazole
Other Names:Methylimidazole
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Daily Chemical Raw Materials
Appearance:Clear Colorless to Yellow Liquid
EINECS No.:210-484-7
Storage:Store Below +30°C.
Provide:1-Methylimidazole MSDS;
1-Methylimidazole COA

What is 1-Methylimidazole?

Imidazole is an extremely essential great chemical raw material and also intermediate, and also it has a vast array of uses. Imidazole exists not just in purine amino acids in ribose as well as deoxyribonucleic acid, however also in amino acids, as well as is likewise an efficient architectural part of many chemicals, enzyme inhibitors, drugs and fine chemicals, so imidazole as well as its by-products have constantly been examined. location. Since imidazole and its derivatives have two nitrogen atoms in the imidazole ring, which can function as a mild electron contributor, imidazole is likewise one of the most generally used functional teams in change steel organic chemistry.

N-methylimidazole is 1-methylimidazole, primarily used as organic synthesis intermediates, ionic liquids and also resin curing representatives, adhesives, and so on and also glass fiber reinforced plastics and various other areas. Therefore, optimizing the synthesis procedure of N-methylimidazole has excellent application worth and useful importance. Presently, the research study on the prep work approaches of N-methylimidazole mostly focuses on the synthesis of 1,2-dicarbonyl substances, the Van Leusen synthesis, the Phillips synthesis, the Wohl-Marckwald synthesis, the Witting synthesis and also the N-methylation synthesis. Law 6 ways.

The cyclic condensation reaction of aldehyde and ammonia is widely used, but the current production of N-methylimidazole is still dominated by traditional batch reactors and distillation. About 24-36 hours, the conversion rate of glyoxal in one reaction is only about 59%, and the production process will produce more coke-like waste liquid and waste water.

In a word, the preparation of N-methylimidazole by kettle-type liquid-phase reaction has many processes, long cycle, low yield and high energy consumption. The imidazole substitution method is divided into two steps to synthesize N-methylimidazole. The first step is to synthesize imidazole, and then the imidazole reacts with methyl iodide under alkaline conditions to generate N-methylimidazole. Compared with the one-step cyclization method, the imidazole substitution method is longer, has high energy consumption, large amount of sewage, and uses methyl iodide with higher price, which makes the production cost relatively high.

1-Methylimidazole Properties:

Melting point −60 °C(lit.)
Boiling point 198 °C(lit.)
density 1.03 g/mL at 25 °C(lit.)
vapor pressure 0.4 mm Hg ( 20 °C)
refractive index n20/D 1.495(lit.)
Fp 198 °F
storage temp. Store below +30°C.
form Liquid
pka6.95(at 25℃)
color Clear colorless to yellow
Specific Gravity1.031
PH9.5-10.5 (50g/l, H2O, 20℃)
PH Range9.5 – 11.5 at 100 g/l at 20 °C
explosive limit2.7-15.7%(V)
Water Solubility Miscible with water.


Application of N-Methylimidazole

N-methylimidazole is a vital resources for manufacturing pharmaceutical intermediates, made use of for the preparation of losartan, nitazofenone, 1-methylimidazole-5-formyl chloride hydrochloride as well as naphthimidazole hydrochloride, etc; in the field of pesticides, is commonly made use of in the synthesis of fungicides as well as plant growth promoters, for instance: N-methylimidazole is used as a cationic moms and dad to undergo quaternization response to synthesize ionic fluids of imidazoles; on top of that, N-methylimidazole is likewise used in epoxy resins as well as other material treating representatives, adhesives, etc; N-methylimidazole also has a terrific application in the field of spreading and glass fiber enhanced plastics.

Gadobutrol is a gadolinium-containing contrast agent made use of in nuclear spin tomography and has been used in Approved in the indicator “Comparison Zoom in Magnetic Vibration Tomography of the Cranial and also Spine”. By using weak bases such as lithium hydroxide or N-methylimidazole, this technique has the advantage of high throughput without the requirement for seclusion and also intermediate purification of intermediates. In the process, lithium salts can advantageously be recuperated and after that fed back right into the production cycle once more.

Compared to previous art approaches, waste generation is a lot more beneficial since all actions are executed in one “pot”, consequently eliminating mom liquor work-up, cleansing of filter systems, etc. By accurately identifying the ligand material before gadolinium complexation, gadolinium in wastewater can be effectively prevented because the amount of gadolinium can be readjusted as though all metals are complexed by butanol ligands. The technique can be managed with agitators and filter tools.Intermediate clean-up is performed with water only, no drying is required, and subsequent preparations can be carried out directly. This ensures optimal equipment usage and allows semi-continuous operation.

In addition, it can also be used to prepare ionic liquid corrosion inhibitors for oilfield water. Using N-methylimidazole as the starting material, the imidazole-type ionic liquid synthesized by a two-step method is used as the main agent for sustained release, and several other compounds are added as auxiliary retarders. Synthetic oilfield water injection compound corrosion inhibitor with release agent. This method can be carried out in sequence as follows:

(1) At a certain temperature, the N-methylimidazole and bromo-n-butane or benzyl chloride are mixed and reacted under stirring, and after the reaction for several hours, the unreacted substances are washed and removed to obtain the halide of N-methylimidazole.

(2) mixing the product obtained in step (1) with the selected compound, adding a solvent, stirring and reacting at a certain temperature for a period of time, the reaction solution is extracted, washed, and treated by removing the solvent to obtain each target product.

(3) Compounding the product obtained in step (2) with urotropine, OP-10, potassium iodide and thiourea in a certain proportion to obtain a corrosion inhibitor with extremely high corrosion inhibition efficiency. The raw materials required by the invention are simple and easy to obtain, the operation process is simple and safe, the reaction time is short, the cost is low, the yield is high, the corrosion inhibition performance is strong, and the invention is suitable for industrial scale production and has strong practicability.

Preparation of N-Methylimidazole

Method 1: Using glyoxal, methylamine, ammonia water and paraformaldehyde as raw materials, “one-pot method” to synthesize N-methylimidazole:

Weigh 12.0 g (0.4 mol) of paraformaldehyde into a 250 mL three-necked flask, add 30.0 mL (0.4 mol) of 25% ammonia water and 47.0 mL (0.4 mol) of 40% methylamine in turn, and stir vigorously at room temperature. Then, 50.0 mL (0.4 mol) of 40% glyoxal was slowly added dropwise to the reactor through a constant pressure dropping funnel. In order to prevent the temperature from rising sharply during the dropwise addition, a water bath was used to control the reaction temperature during the experiment.

After the dropwise addition, the temperature was kept at a certain temperature and reacted for several hours, and then samples were taken to measure the refractive index after each reaction for a period of time, and compared with the standard refractive index curve of N-methylimidazole to obtain its content and conversion rate. When the conversion rate reaches the experimental requirements, carry out vacuum distillation until almost no water is evaporated, and then add 50.0 mL of azeotrope cyclohexane to refine N-methylimidazole. Distilled at atmospheric pressure until the sample was carried out without water, steamed cyclohexane, and then distilled under reduced pressure to obtain a colorless liquid, which was weighed and the final yield was calculated.

Technique 2: A continuous prep work approach of N-methylimidazole, making use of Hβ molecular sieve as a catalyst, in a tubular activator, blended ammonia consisting of ammonia water and methylamine, and combined aldehyde including formaldehyde and also glyoxal are performed in gas stage. Catalytic reaction, the gotten reaction item is divided by correction to obtain N-methylimidazole. The particular actions are:

( 1) Include Hβ molecular sieve catalyst to the tubular activator, warmth and vaporize the raw material mixed ammonia and combined aldehyde, as well as continuously feed into the tubular reactor, and the mixed gas produced by the gas-phase catalytic reaction is compressed to acquire a crude N-methylimidazole product;

( 2) the N-methylimidazole thick item that action(1) obtains is added into the vacuum side line rectifying tower rectifying and separating, and the control pressure of the vacuum side line rectifying tower is 0.20MPa, and the vacuum side line rectifying tower side line discharge is the content ≥99.0wt% of N-methylimidazole, the top of the vacuum side-line rectification tower obtains water with a purity of more than 99.0wt%, and the bottom discharge of the vacuum side-line rectification tower contains high boiling point N-methylimidazole mixture;

(3) the water that the purity obtained at the top of the decompression side-line rectifying tower is added to the rectifying tower at a purity of more than 99.0 wt %, is separated through rectification, and the aqueous solution of mixed ammonia and mixed aldehydes obtained at the top of the rectifying tower tower is recycled as a raw material, The bottom discharge of the rectification tower is water.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

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Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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