1-Eicosanol CAS 629-96-9

In a completely dry response container outfitted with a stirrer, ventilation tube, reflux condenser (mounted with a calcium chloride drying tube) and going down funnel, add 5.5 g (0.23 mol) of magnesium strips and cover with anhydrous ether. Add 1-bromooctadecane (66g, 0.2 mol) and 70mL dry diethyl ether to the dropping channel and blend equally. Add regarding 5mL first, then add 0.5 mL methyl iodide to launch the response. After the response started, the continuing to be 1-bromooctadecane option was slowly added dropwise. The enhancement was completed in about 3 hours, and afterwards the response was refluxed for 3 hours. Awesome, after that warm 50 mL of diethyl ether, and come on ethylene oxide (2) while cooling in an ice-salt bathroom. The response is exothermic and the response system slowly comes to be thick up until it can not mix, and the circulation of ethylene oxide is stopped.

Right now, a large quantity of magnesium substance crystals precipitate and a huge amount of heat is launched. Include water down hydrochloric acid decomposition products, heat in a water bath, and divide the oil layer. The aqueous layer was removed with benzene. Combine the oil layer and benzene layer. Crystallizes on cooling. Filter and dry to obtain about 20g of 1-eicosanol (1 ).

The product can be detoxified by recrystallization with benzene as the solvent, or by purification under lowered stress, and the portion at 213 ~ 216 ℃/ 1.5 kPa is gathered.