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Zhishang Chemical

1-Bromobutane CAS 60719-84-8

Molecular Formula: C10H9N3O

Formula Weight: 187.2

ZSpharmac: 1-Bromobutane Supplement

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Product Name: 1-Bromobutane
CAS No: 60719-84-8  
Purity: 99%

Basic Info

Product Name:1-Bromobutane
Other Names:Amrinon
CAS:60719-84-8
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Clear Colorless to Light Yellow Liquid
EINECS No.:203-691-9
Storage:Store Below +30°C.
Provide:1-Bromobutane  MSDS;
1-Bromobutane COA

What is 1-Bromobutane ?

Bromobutane, also known as 1-bromobutane, is an important fine chemical product, mainly used as an alkylating agent in organic synthesis; Intermediate; organophosphine compound tributylphosphine, phase transfer catalyst and surfactant tetra-n-butylammonium bromide. It is also used as a solvent, an extractant for rare elements, as a raw material for the synthesis of pesticides, medicines, dyes, and spices, and as a refrigerant and solvent.

1-Bromobutane Properties:

Melting point -112 °C
Boiling point 100-104 °C(lit.)
density 1.276 g/mL at 25 °C(lit.)
vapor density 4.7 (vs air)
vapor pressure 150 mm Hg ( 50 °C)
refractive index n20/D 1.439(lit.)
Fp 23 °C
storage temp. Store below +30°C.
solubility 0.6g/l
form Liquid
color Clear colorless to light yellow
Odorcharacteristic odor
explosive limit2.8-6.6%, 100°F
Water Solubility 0.608 g/L (30 ºC)

 

1-Bromobutane Uses

  1. 1-Bromobutane is an intermediate between the fungicides dimethylphenol and pyrimethamine.
  2. 1-Bromobutane is used in the synthesis of the anesthetic tetracaine hydrochloride and in the production of dyes and fragrances.
  3. 1-Bromobutane is used as a rare element extraction agent, an alkylating agent and a raw material for organic synthesis. It can also be used as a raw material for medicines, dyes and spices as an intermediate for medicines, dyes and pesticides.

Preparation of 1-Bromobutane

Preparation[1]
The existing synthesis technology of bromobutane mainly includes n-butanol and sodium bromide sulfuric acid method, n-butanol and hydrobromic acid sulfuric acid method, n-butanol and hydrobromic acid solid acid catalysis method, n-butanol and bromine sulfurization method. and so on.
According to reports in the literature, most domestic manufacturers use the sodium bromide sulfuric acid process route. However, this method is intermittent production, the amount of catalyst concentrated sulfuric acid is large, and a large amount of dilute sulfuric acid is produced as a by-product, which is very serious to environmental pollution. The production cost of the product is high, the product content is low, the equipment is seriously corroded, and the utilization rate is low. Environmental protection treatment or raw material recovery The utilization is relatively complicated, and the processing cost is high, which increases the production cost.
Hydrobromic acid and n-butanol react in the presence of a catalyst to produce 1-bromobutane. Since hydrobromic acid is a by-product of mass production of aryl bromide flame retardants, it is economically reasonable and has been a research hotspot in recent years. Sulfuric acid as a catalyst will produce a large amount of dilute sulfuric acid in the production process, and the post-treatment is relatively troublesome; the solid acid catalysis method is easily affected by the failure of the catalyst, resulting in unstable product yield, and the complex synthesis and regeneration process of the catalyst affects the promotion of this process. . Chinese invention patent CN102826954 discloses a “preparation method of bromoalkane”, which is mixed according to the molar ratio of n-butanol and hydrobromic acid of 1:5, heated to a reflux state, and continuously and uniformly added dropwise and the gas outlet speed is adjusted to make the liquid The amount of dripping and the amount of steaming out are corresponding to keep the kettle liquid stable. However, this method has a long reaction time, needs 6-12 hours, and has a large amount of hydrobromic acid and a low utilization rate.
Chinese invention patent CN102766013A discloses a “environmentally friendly method for preparing bromoalkane”. First, a certain amount of hydrobromic acid solution is preheated in a reactor until steam is generated, and the molar ratio of n-butanol and hydrobromic acid is 1 : 1 was mixed and added to the reactor, while raising the reaction temperature. However, the reaction time of this method is still long, and it is a batch production, which cannot be continuously produced.
Chinese invention patent CN102875323B discloses a method for preparing bromo-tert-butane by brominating tert-butanol in a microchannel reactor. Using concentrated sulfuric acid as a catalyst, tert-butanol and hydrobromic acid are reacted in a micro-channel reactor to prepare tertiary bromide. Butanol. However, this method still uses concentrated sulfuric acid, so it is necessary to deal with the problem of equipment corrosion caused by concentrated sulfuric acid and the problem of environmental pollution caused by waste acid.
Therefore, there is still a need to develop new processes for producing 1-bromobutane with high efficiency, high yield, high selectivity, low cost, low by-products, and no pollution. CN201810594072.1 provides a continuous process for preparing bromobutane in a microchannel reactor. Compared with the existing process, the process has the advantages of precise control of reaction conditions, no catalyst, short reaction time, good selectivity, high yield, few by-products, high product purity, flexible, safe and efficient operation. An example is as follows:

Using a plunger pump, 48wt% hydrobromic acid and 99wt% n-butanol were continuously passed to the microchannel reactor, the feeding rate of the measured n-butanol was 5g/min, and the feeding rate of hydrobromic acid was 13.6g/min, That is, the molar ratio of n-butanol and hydrobromic acid is 1:1.2. After feeding, adjust the temperature and pressure of the reactor, use the refrigeration heating temperature control system to adjust the system temperature to 140 °C, and use the pressure valve to adjust the front pressure of the system to 1.5MPa, no bubbles appear in the reaction section, and the residence time is 260s. The reaction was quenched by running tap water in the last module of the reactor. After the material feed amount, reaction temperature and reaction pressure were stabilized, sampling was performed after waiting for 3 residence times. The sample was left to stand for stratification, and the separated oil phase was washed with saturated sodium carbonate solution to pH=7, then washed with water, and dried with anhydrous magnesium sulfate in the laboratory to obtain 1-bromobutane with a purity of 95%. The conversion of butanol was 94%.

1-Bromobutane Operation Process

Notes on operation:
1. The feeding sequence cannot be reversed; after feeding, it must be mixed evenly.
2. Use the feeding funnel to add the solid raw materials to ensure that the bottle mouth of the round-bottomed flask is clean, and the grinding mouth connection of the device must be tight, and no air leakage shall be allowed.
3. During the reaction, keep the backflow running smoothly to prevent the gas absorbing pipe from sucking back.
4. When washing the crude product, pay attention to correctly judge the relationship between the upper and lower layers of the product.
5. The amount of desiccant should be reasonable and the time should be sufficient.
6. The instruments required for the final distillation need to be dried in advance and ready for use.
When using a separatory funnel, it is best to temporarily leave all the separated liquid layers until the end of the whole experiment, so that once the wrong organic layer is found, it can be remedied in time.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vision
Become the most trusted chemical supplier in the world
Our Business Philosoty
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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