β-Sitosterol CAS 83-46-5

Molecular Formula: C29H50O

Formula Weight: 414.72

ZSpharmac: β-Sitosterol Supplier

Product Name: β-Sitosterol

CAS No: 83-46-5

Purity: 99%

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Basic Info

Product Name:	β-Sitosterol
Other Names:	Beta-Sitosterol
CAS:	83-46-5
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White to Off-White White Solid
EINECS No.:	201-480-6
Storage:	2-8°C
Provide:	β-Sitosterol MSDS； β-Sitosterol COA

What is β-Sitosterol?

Sterol (sterol) is a sort of steroid compound (steroid) existing in nature, although its material is very little, however it has high application worth. Since it is strong, it is additionally called sterol, which comes from macromolecular alcohols. It is the primary part of unsaponifiable issue in oils. According to different sources, sterols can be separated right into three classifications, specifically animal sterols, β-Sitosterols as well as mycosterols.

β-Sitosterol has amphoteric attributes that make it capable of binding as well as regulating the fluidness of reversed-phase membranes; on the other hand, phytosterols are mainly hydrophobic, yet as a result of their structure with hydroxyl groups, they have a particular degree of hydrophilicity The bigger the side chain, the stronger the hydrophobicity of the sterol. The specific gravity of β-Sitosterol is somewhat larger than that of water. It is insoluble in water as well as soluble in various organic solvents.

β-Sitosterol (sitosterol) is taken into consideration to be a mild complimentary radical scavenger, which clarifies to some extent the favorable effects of phytosterols in maintaining cell membrane layer security, inhibiting inflammation, protecting against atherosclerosis as well as anti-cancer. Anti-inflammatory and also immunomodulatory impacts β-Sitosterol has anti-inflammation, anti-infection, and also restraint of bacterial and also fungal recreation, and its anti-inflammatory result is likewise among the functions uncovered earlier.

β-Sitosterol Property

Melting point	136-140 °C(lit.)
alpha	-28 º (c=2, CHCl3)
Boiling point	473.52°C (rough estimate)
density	0.9540 (rough estimate)
refractive index	1.5000 (estimate)
storage temp.	2-8°C
solubility	chloroform: 20 mg/mL, clear, colorless
form	White solid
pka	15.03±0.70(Predicted)
color	White to Off-White
Water Solubility	INSOLUBLE

β-Sitosterol Uses

β-Sitosterol and β-sitosterol by-products are widely utilized in medication, food, cosmetics, feed and also various other industries as a result of their unique organic and also physical and also chemical residential properties.
β-Sitosterol has the features of reducing cholesterol, eliminating cough, eliminating phlegm, hindering growth and fixing tissues. For type II hyperlipidemia, atherosclerosis as well as persistent bronchitis, additionally for very early cervical cancer cells and also skin abscess. Gastrointestinal responses such as anorexia nervosa, diarrhea, and also intestinal discomfort might occur in huge doses. Abscess triggered by osteomyelitis should not be made use of prior to the main illness has actually recovered. Calf abscess with varicose blood vessels of the reduced extremities must be treated with varicose capillaries at the same time.
A research of β-Sitosterol supplementing the diet of computer mice located that it had a significant result on body mass buildup.
β-Sitosterol is a phytosterol whose structure is extremely comparable to cholesterol and also has estrogenic activity. It inhibits proliferation (G2/M arrest), endoduplication, as well as polymerization of α-tubulin and microtubules in human leukemia cells.

Production Method of β-Sitosterol

A kind of production method of high-content β-sitosterol, with the vegetable oil deodorization distillate that contains 4～7% β-sitosterol as raw material, comprises esterification, alcoholysis, short-range separation, cold analysis, filtration, filtration The steps of cake washing and vacuum drying are characterized in that:

(1) Esterification: take the deodorized distillate in the vegetable oil refining process as raw material, use acid as catalyst, take methanol as reaction solvent, solvent weight is 30%～40% of raw material amount, and catalyst weight is 0% of raw material weight .06～0.07 times, at 70～80 ℃, carry out esterification reaction 3～4 hours, leave standstill, separate and remove unreacted solvent and catalyst mixed solution;

(2) alcoholysis: add alkali catalyst and reaction solvent methanol in the esterified oil obtained after the reaction, the weight of alkali catalyst is 0.01～0.015 times of raw material weight, and solvent weight is 0.15～of raw material weight 0.20 times amount, temperature 70 ℃～80 ℃, carry out alcoholysis reaction 1～2 hour;

(3) washing: the above-mentioned reaction product is washed 3 to 4 times with hot water of 70 to 80° C., until the pH is 8 to 7;

(4) short-range separation: the reaction product after above-mentioned washing is at 150～160 DEG C, under 50～100½ vacuum, by short-range distillation separation device, feeds 4～5 liters per minute, separates fatty acid methyl ester;

(5) cold analysis, filtration: the heavy component after above-mentioned distillation enters filter press filter when 70～80 ℃, removes impurity, and filtrate enters cold analysis kettle, adds regulator and carries out cold analysis, and regulator is made of 10% sulfuric acid Form by 1: 2.5～3.5 weight ratio proportioning with water, the weight ratio of heavy part and regulator is 1: 0.03～0.04, cold analysis is to 30～40 ℃, press filtration obtains crude product β-sitosterol;

(6) washing, vacuum drying: filter cake after above-mentioned filtration, add ethanol and wash under normal temperature stirring, filter solvent, dry to obtain the β-sitosterol finished product that content is more than 80% through 70～80 ℃ of drying.

β-Sitosterol Protects Against Obesity-Associated Chronic Inflammation

The physical duty of β-Sitosterol in persistent swelling is believed to be associated with the underlying systems of metabolic disease, however has actually not been illuminated. Therefore, in this research, we intended to illuminate the physical role of β-Sitosterol in professional researches and pet experiments. We observed a relatively particular inverse correlation in between serum sitosterol levels as well as product IL-6 and TNF-α levels in diabetic subjects (n=46) and non-diabetic topics (n=178). Several regression evaluation also revealed that serum IL-6 and TNF-α levels were highly inversely correlated with lotion β-Sitosterol degrees. When ABCG5/8 KO mice with considerably elevated plasma β-Sitosterol levels and ABCG5/8 xenogeneic mice were fed a high-fat diet, we observed body weight gain, fatty liver adjustments, and perigonadal modifications in ABCG5/8 KO computer mice. The expansion of adipose tissue was reduced with no regulation of food intake. We also observed the plasma IL-6 and TNF-α degrees, the expression of TNF-α as well as PAI-1 in the liver and also the expression of IL-6, TNF-α as well as MCP-1 in the adipose tissue in ABCG5/8 KO mice tool reduced. These results recommend that β-Sitosterol might suppress obesity-associated chronic inflammation and also might apply in the treatment of metabolic illness. ABCG5/8 KO mice had lower degrees of TNF-α as well as MCP-1 in fat. These results suggest that sitosterol might subdue obesity-associated chronic swelling and also might be applicable in the therapy of metabolic illness. ABCG5/8 KO computer mice had lower levels of TNF-α and also MCP-1 in adipose tissue. These results suggest that β-Sitosterol might subdue obesity-associated persistent swelling and may apply in the therapy of metabolic illness.

About That Product:
If you need β-Sitosterol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of β-Sitosterol, ZSpharmac will provide β-Sitosterol raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.