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β-Nicotinamide Mononucleotide CAS 1094-61-7

Molecular Formula: C11H15N2O8P

Formula Weight: 334.22

ZSpharmac: β-Nicotinamide Mononucleotide Raw Material Supplier

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Product Name: β-Nicotinamide Mononucleotide
CAS No: 1094-61-7
Purity: 99%

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Basic Info

Product Name:β-Nicotinamide Mononucleotide
Other Names:BETA-NMN
CAS:1094-61-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Yellow Solid
EINECS No.:214-136-5
Storage:-20°C
Provide:β-Nicotinamide Mononucleotide MSDS;
β-Nicotinamide Mononucleotide COA

What is β-Nicotinamide Mononucleotide?

Nicotinamide mononucleotide, likewise called β-nicotinamide mononucleotide (NMN), is a fabricated substrate for coenzyme I. NMN is furthermore used in anti-aging research study. Studies have in fact disclosed that β-NMN can likewise control the secretion of insulin and likewise affect the expression degree of mRNA. β-NMN has broad application possible consumers in the field of medical therapy.
β-Nicotinamide mononucleotide is the item and necessary NAD+ intermediate of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) action. It improves sugar tolerance by revive NAD+ degrees in HFD-induced T2D computer mice. It additionally boosts hepatic insulin level of level of sensitivity and recovers genetics expression pertaining to oxidative stress, inflammatory comments, and body clocks, partly through SIRT1 activation.

β-Nicotinamide Mononucleotide Property

Melting point 166 °C(dec.)
storage temp. -20°C
solubility DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form Solid
color White to Yellow

 

β-Nicotinamide Mononucleotide Applications

β-Nicotinamide mononucleotide is the forerunner of NAD+, the cofactor of toughness protein in the body. NAD+ is a vital coenzyme in the tricarboxylic acid cycle, advertising the metabolism of sugar, fat, and amino acids, and taking part in the synthesis of power; NAD+ is the only substratum for coenzyme I consuming enzymes (the just substratum for the DNA repair work enzyme PARP, and the only substratum for the lengthy life healthy and balanced protein Sirtuins Substratum, the only substratum of cyclic ADP-ribose synthase CD38/157).
NAD+ is associated with all aspects of human metabolic process and is an essential coenzyme. Without NAD+, metabolic procedure will certainly not work. Senior people do not have NAD+, so different substantial and small troubles emerge. By supplementing included NAD+, you can thoroughly withstand aging.
Preclinical study studies have shown that NMN has several medical tasks in heart and analytical anemia, Alzheimer’s disease, kind 2 diabetes mellitus and weight troubles caused by diet plan and age. As a prodrug of NAD+, NMN normally contributes in the synthesis of NAD+ in the body. Medicinal results, all of which are connected with NAD+ shortage.

Physiological Applications of β-Nicotinamide Mononucleotide

Great deals of pet dog experiments have in fact revealed that resilient regular supplements of β-nicotinamide mononucleotide can correctly raise the biosynthesis of NAD+ in numerous outer cells, including pancreas, liver, fat, heart], skeletal muscular tissue, kidney, testis, ovary, Retina, capillary (aorta) and mind cells. This improvement is not limited to typical computer mice, however additionally consists of diet-induced overweight computer mice and various other pathological model computer mice. In a singular acute β-nicotinamide mononucleotide supplementation experiment in computer mice, plasma β-nicotinamide mononucleotide levels increased 2.5 minutes after dental management of β-nicotinamide mononucleotide (300 mg/kg megabytes), and went down to regular levels after increasing for pertaining to 15 mins, and after that the liver NAD+ level gradually enhanced at half an hour. NAD+ degrees were a little enhanced in skeletal muscle mass and cerebral cortex 60 mins after oral monitoring of β-nicotinamide mononucleotide. This suggests that supplemented β-nicotinamide mononucleotide can be swiftly taken in into the blood stream and swiftly metabolized to NAD+ in various major body organs.

In relation to dosage and security of β-nicotinamide mononucleotide, most animal experiments use a dosage of 100 to 500 mg/( kg megabytes · d). Present research studies have actually disclosed that in normal wild-type C57BL/6 computer system mice, long-lasting (1 year) oral management of β-nicotinamide mononucleotide (300 mg/kg mb) is safe and well tolerated without any substantial harmful or hazardous outcomes.

The first thing to note is that beta-nicotinamide mononucleotide can considerably increase metabolic feature Pancreatic β-cells are actually conscious the reduction in NAD+ degrees and β-nicotinamide mononucleotide intervention. Supplementing β-nicotinamide mononucleotide can considerably enhance pancreatic β-cell insulin secretion and outer tissue insulin sensitivity, for that reason boosting age and Sugar resistance and insulin resistance in diet-induced diabetic and maturing computer mice. In adipocyte-specific NAMPT ko computer mice (ANKO), dental administration of NMN also boosted fat NAD+ biosynthesis and SIRT1 job and stabilized serious hypoadiponectinemia and multi-organ insulin resistance. On top of that, long-term monitoring of NMN minimized age-related fat swelling and improved systemic insulin level of sensitivity in conventional diet-fed wild-type C57BL/6 computer system mice. Considering that fat NAD+ biosynthesis is drastically harmed in obese and aged computer mice, these findings recommend that fat NAD+ might be an outstanding corrective target for insulin resistance, an important risk variable for kind 2 diabetes mellitus and heart disease.

Administration of β-nicotinamide mononucleotide can also partially avoid the surge in body weight of computer mice fed a high-fat diet plan program by elevating power expense. Mice taking β-nicotinamide mononucleotide for a very long time disclose better energy expenditure and Workout protects against weight gain throughout aging. Therefore, use β-nicotinamide mononucleotide may improve diet plan program- and age-related weight gain.

The main systems of β-nicotinamide mononucleotide control sugar and lipid metabolic rate and enhance cells insulin resistance include revive NAD+ biosynthesis, enhancing SIRT1 job, easing swelling and oxidative anxiety, controling circadian rhythm-related genetics expression, and enhancing body power. consumption.

The first thing to note is that beta-nicotinamide mononucleotide can considerably increase metabolic feature Pancreatic β-cells are actually conscious the reduction in NAD+ degrees and β-nicotinamide mononucleotide intervention. Supplementing β-nicotinamide mononucleotide can considerably enhance pancreatic β-cell insulin β-Nicotinamide mononucleotide improves mitochondrial feature.
Beta-nicotinamide mononucleotide boosts mitochondrial feature in different metabolic body organs, containing skeletal muscle mass, liver, heart, and retina. Mitochondrial oxidative phosphorylation is boosted in skeletal muscular tissue of NMN-treated computer system mice and promotes weight management by boosting systemic power expenditure. Increased citrate synthase task in liver mitochondria in high-fat diet-fed obese computer mice.

Long lasting administration of beta-nicotinamide mononucleotide improves age-related insulin resistance and lowers age-related adjustments in genetics expression. After senior computer mice are used β-nicotinamide mononucleotide, the respiratory system capability of skeletal muscle mitochondria can additionally be better preserved, which will absolutely help elevate the body’s power consumption and boost sugar resistance.

Supplementing NMN can likewise assist relieve the decrease in reproductive ability old female computer mice. Researches have actually uncovered that including β-nicotinamide mononucleotide can enhance NAD+ and NAD(P)H in oocytes of computer mice with lowered fertility. level. β-Nicotinamide mononucleotide-treated mice in addition revealed enhanced fertility and enhanced oocyte production, along with renovations in clutter measurement and live trash size. NMN treatment of aged computer mice can furthermore have an equivalent reversal influence on mind attribute and can improve the spatial functioning memory function and stride control of aged computer mice. This may be linked to Sirtuins-mediated transcriptomic changes in neural cells and vascular endothelial cells.

β-Nicotinamide Mononucleotide Preparation

Include 150 ml of phosphate obstacle remedy to a 500 ml four-neck container.
Include 2g magnesium chloride, 10g ATP, 7g ribose, and 10g nicotinamide at once, and keep mixing at 35 ° C. Evaluate the pH value of the feedback system, and change pH = 8.0 with 10% Na2CO3 treatment, after that consist of 1g RK enzyme powder and 2g NAMPT enzyme powder, stir and liquify.
Stir the response at 37 ° C and 200 rpm, and take advantage of liquid chromatography-mass spectrometry to examine the conversion rate of the reaction. After 6 hours of action, it is spotted that ATP has been taken in and the response is stopped. Via further filtration, HZ-818 macroporous resin adsorption, suspended animation, and recrystallization from ethanol and water, β-nicotinamide mononucleotide-nicotinamide mononucleotide NMN can be gotten with a return of 70%.

About Products:
If you need β-Nicotinamide Mononucleotide, a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced β-Nicotinamide Mononucleotide manufacturer and supplier, ZSpharmac will provide β-Nicotinamide Mononucleotide raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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