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Zhishang Chemical

β-Nicotinamide Mononucleotide CAS 1094-61-7

Molecular Formula: C11H15N2O8P

Formula Weight: 334.22

ZSpharmac: β-Nicotinamide Mononucleotide Supplement

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Product Name: β-Nicotinamide Mononucleotide
CAS No: 1094-61-7
Purity: 99%

Basic Info

Product Name:β-Nicotinamide Mononucleotide
Other Names:BETA-NICOTINAMIDE MONONUCLEOTIDE;NMN
CAS:1094-61-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Yellow Solid
EINECS No.:214-136-5
Storage:-20°C
Provide:β-Nicotinamide Mononucleotide MSDS;
β-Nicotinamide Mononucleotide COA

What is β-Nicotinamide Mononucleotide?

β-nicotinamide mononucleotide – nicotinamide mononucleotide, also referred to as β-nicotinamide mononucleotide (NMN), is an artificial substrate of coenzyme I, as well as NMN is additionally utilized in anti-aging study. Together with Keio University in Japan and also the College of Washington in the USA, human clinical tests are being carried out on the anti-aging result and also safety of β-NMN. Researches have actually shown that β-NMN can also control the secretion of insulin and likewise affect the expression degree of mRNA. β-NMN has a large range of application potential customers in the field of clinical treatment. It also boosted hepatic insulin level of sensitivity and also recovered gene expression related to oxidative anxiety, swelling, as well as circadian rhythms, partially with SIRT1 activation.

β-Nicotinamide Mononucleotide Properties:

Melting point 166 °C(dec.)
storage temp. -20°C
solubility DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form Solid
color White to Yellow

 

Research and Application Progress of β-Nicotinamide Mononucleotide (NMN)

β-Nicotinamide Mononucleotide (NMN) is an intermediate in the salvage synthesis pathway of nicotinamide adenine dinucleotide (NAD+) in mammals. NMN is converted into NAD+ in humans to exert its physiological functions, such as activating NAD+ substrate-dependent The enzyme Sirt1 (histone deacetylase, also known as sirtuin protein), regulates cell survival and death, maintains redox state, etc. Recent research studies have actually found that by managing the degree of NMN in the body, it has a good treatment and also fixing effect on cardio as well as cerebrovascular illness, neurodegenerative illness and also maturing degenerative illness; It can secure as well as fix island feature, boost insulin secretion, and also avoid and also treat metabolic conditions such as diabetes mellitus and also obesity.

β-Nicotinamide Mononucleotide protects against cerebral ischemia-induced neuronal apoptosis by boosting the bioenergy metabolism of post-ischemic cells, as well as promotes nerve regrowth after analytical anemia. For that reason, NMN has a strong safety result on ischemic brain injury. For hemorrhagic brain injury, enhancing the degree of β-Nicotinamide Mononucleotide can reduce the web content of hemoglobin in infarcted tissue, lower hemorrhage as well as edema, and also minimize the oxidative toxicity damages of mind tissue caused by oxidative stress and anxiety.

The NAD+ content in the heart decreased after ischemia, as well as exogenous NMN might boost the NAD+ and also NADH material in the heart and reduce the infarct size.

β-Nicotinamide Mononucleotide boosts behavioral and cognitive problems in mice with Alzheimer’s disease by triggering c-Jun N-terminal kinase, hinders β-amyloid manufacturing, as well as decreases the problem of amyloid plaques in the nerves. responsive injury and inflammatory feedbacks.

β-Nicotinamide Mononucleotide can improve neuronal survival, decrease apoptosis, recover NAD+ as well as ATP levels, prevent apoptosis, withstand power damages, as well as boost mitochondrial inhibitor-induced basal metabolism problems.

The study found that NMN supplements increased the turn over of NAD+ salvage biosynthesis, thereby activating the Sirt1 response. Sirt1 can induce DNA silencing as well as add to anti-aging and also durability.

Researches have found that NMN can improve islet dysfunction in mice in high fructose team, turn around the adjustments in the expression of genetics inscribing island pens moderated by pro-inflammatory cytokines, minimize the expression of pro-inflammatory factors, restore insulin secretion, and enhance cytokine-mediated islet expression. disfunction.

Researches have actually shown that levels of Sirt1 and NAD+ decrease with age; minimized NAD+ and also Sirt1 in the kidneys of aged microorganisms lead to raised sensitivity to AKI; supplements with NMN protects mice from cisplatin, which can be utilized to prevent DNA duplication. )- caused AKI; the system whereby NAD+/ Sirt1 shields the kidney entails epigenetic guideline of the JNK path.

Supplements with β-Nicotinamide Mononucleotide can minimize collagen buildup throughout the blood vessels, increase arterial elastin buildup, decrease arterial tightness, as well as hold-up arterial aging that accompanies age. In addition, NMN can also enhance lipid distribution in plasma and also keep blood sugar level degrees, thereby enhancing vascular feature.

NMN supplementation brought back regular basic glycolytic feature, mitochondrial function, and the ability to adapt to metabolic stress and anxiety, decreased photoreceptor cell death, as well as considerably enhanced dark vision and also retinal function in mice.

Workout is a reliable way to withstand obesity. This is because workout results in a rise in the degree of NAD+, which boosts mitochondrial basal metabolism, and also NMN can likewise boost the level of NAD+. Therefore, in theory, the management of β-Nicotinamide Mononucleotide can attain the very same weight reduction impact as workout. Studies have actually contrasted the effects of NMN supplements and workout on anti-obesity, as well as the outcomes show that NMN supplementation raises fat assimilation as well as enhances NAD+ degrees in the liver, while exercise mostly increases the degree of NAD+ in muscles, which suggests that NMN based upon NAD+ precursors. Potential for usage in the therapy of obesity-related liver conditions such as nonalcoholic fatty liver condition.

As an intermediate in the NAD+ salvage pathway, nicotinamide mononucleotide has anti-oxidative as well as oxidative stress-reducing effects, and is utilized in the therapy of some details diseases, such as stroke, heart ischemia-reperfusion, Alzheimer’s disease, It likewise has excellent performance in Parkinson’s disease, intense kidney injury, retinal degenerative illness, as well as type 2 diabetic issues. Specifically in regards to anti-aging, β-Nicotinamide Mononucleotide can decrease the physical decrease of the microorganism, boost basal metabolism, and also prolong lifespan.

The Mechanism of Action of β-Nicotinamide Mononucleotide

In fact, the mechanism of action of β-Nicotinamide Mononucleotide is achieved by supplementing the essential coenzyme NAD+ of the human body. Direct supplementation of NAD+ cannot be absorbed by cells, and many scientific experiments have proved that supplementing its precursor, β-Nicotinamide Mononucleotide, can effectively increase the level of NAD+ in the body. So what is the effect of NAD+ on the human body? Take a look

The role and efficacy of supplementing coenzyme I (NAD+)

At the age of 60, the web content of coenzyme I (NAD+) in the body is less than a quarter of that at the age of 20, which activates numerous signs and symptoms of aging in the body, such as amnesia, weakened cardiovascular function, reduced resistance, poor sleep quality, and also decreased energy., irregular bowel movements, hair loss as well as anorexia nervosa, etc. In the past 3-4 years, one of the most authoritative academic journals on the planet, Scientific research, Nature, and also Cell, have constantly published human as well as animal researches, consistently confirming that supplements of β-Nicotinamide Mononucleotide can successfully increase as well as recover the degree of Coenzyme I in the body, significantly hold-up aging and protect against Alzheimer’s Nerve cell degenerative conditions such as condition, and hence basically control and also enhance different symptoms of aging. Other studies have likewise entailed cancer cells, inability to conceive, excessive weight, cerebral hemorrhage, heart failure, heart damage, vascular aging, acute renal failing, diabetes mellitus, and so on, showing that supplementation of β-Nicotinamide Mononucleotide has multiple medical and medical care possibilities.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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